Best cbd oil for cluster headaches

Best CBD Oil for Migraines

If you have tried just about every standard over-the-counter painkiller for migraines without much effect, you might want to consider using cannabidiol (CBD) oil for relief. Below are some of the best CBD oil products that we recommend to relieve your headaches and the pain associated with migraines.

Spruce 750mg Lab Grade CBD Oil
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement

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Best CBD Purity

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes

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Best High Potency

Spruce 2400mg Lab Grade CBD Oil
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle

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Avida Full Spectrum CBD Oil Tincture 500mg
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC ( <0.3)

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cbdMD CBD Oil Tincture Natural 1500mg
  1. made using only CBD sourced from medical hemp
  2. available in many flavours
  3. safe for daily use

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CBDistillery THC Free CBD Oil Tinctures
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers

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Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan

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Best For Beginners

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum

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Best Flavor Range

Hemp Bombs 750mg CBD Oil
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription

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Best CBD Oil for Migraines 2022

    Editor’s Pick Best Organic Editor’s Pick Best Seller Best Natural Alternative Best THC-Free Best Customer Rated Best Starter Best Flavor Range

Compare the best CBD Oil for Migraines 2021

Best CBD Oil for Migraines

1. Spruce 750mg Lab Grade CBD Oil
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Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
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Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
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The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
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Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
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cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
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CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
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This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
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A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
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Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

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How CBD Works for Migraines

CBD interacts with the human body’s endocannabinoid system (ECS) to help regulate pain sensation s . The ECS maintains the body’s equilibrium and keeps balance in several bodily functions , such as mood, appetite, metabolism, anxiety, memory, sleep, and immune response.

A 2018 study noted that migraine and several mental state disruptions are connected to disturbances to the functionality or supply of endocannabinoids (1) . A separate study reported that cannabinoids , such as CBD and THC (tetrahydrocannabinol) , may help reduce neuropathic, acute, and chronic pain (2) . Cannabinoids are compounds that occur naturally in Cannabis sativa plants.

The ECS contains cannabinoid receptors located in different parts of the body, mainly distributed throughout general pain sensation pathways (3) . These pain pathways are mostly found in the peripheral nervous system (PNS) and the central nervous system (CNS).

CBD and other cannabinoids, both natural and synthetic, bind to the endocannabinoid receptors, which affects the body’s functionality.

CB1 and CB2 are the primary types of cannabinoid receptors associated with the ECS.

CB1 receptors are associated with cognitive functions (4) . These include movement, emotion, mood, thinking, memories, pain, and appetite. Meanwhile, CB2 receptors are associated with pain and inflammation (5) .

Although cannabinoid receptors are found throughout the body, certain types tend to be concentrated in one area more than others. For instance, CB1 receptors are abundant in the brain, making them a potential target for treating migraines (6) .

Meanwhile, CB2 receptors are prevalent in the immune system (7) . These receptors have potential anti-inflammatory properties and represent an alternative response to migraine (8) .

CB1 and CB2 receptors also interact with anandamide, a naturally occurring cannabinoid in the body (9) . In 2011, researchers collected data from an animal model and examined the effects of anandamide on migraine . The authors’ study is published in the Journal of Headache and Pain (10) .

Upon combining their data with related literature, the researchers hypothesized that a dysfunction in the endocannabinoid system potentially contributes to the development of migraine attacks.

The same study suggested that the pharmacological modulation of CB1 and CB2 receptors may be useful in treating chronic migraine pain.

Meanwhile, a 2017 study presented evidence that migraine sufferers have anandamide deficiency (11) . The study’s researchers noted that migraine is not associated with a generalized anandamide deficiency. Instead, they attributed migraine to a localized deficiency.

How CBD Works for Tension Headaches and Cluster Headaches

In chronic tension headaches and cluster headaches, existing research focuses on assessing massage therapy effects in alleviating pain from these conditions. Tension headaches occur when the scalp and neck muscles contract and become tense. Meanwhile, cluster headaches are one-sided head pains that occur in cyclical patterns or “cluster periods.”

In a 2002 study with human subjects, researchers provided structured massage therapy treatment to patients (12) . Massage therapy targeted the patients’ neck and shoulder muscles.

Although the results did not yield any positive effect s on headache intensity, researchers noted that the duration of headaches decreased during massage periods.

As such, the researchers stated that muscle-specific massage therapy might help reduce chronic tension headaches.

CBD products come in transdermal options, which you can apply directly to your skin . When applied topically, they may have some potential benefits in relieving pain and inflammation.

There is no substantial evidence to support CBD oil’s benefits in treating tension headaches. However, coupling CBD oil products with massage therapy may increase the migraine relief offered by both treatment options compared to when used separately.

Benefits of Using CBD for Migraines

Several studies have backed CBD’s purported benefits in relieving migraine symptoms, including headaches, vomiting, nausea, inflammation, and general pain. Moreover , the World Health Organization (WHO) showed approval for CBD, saying that it is “generally well-tolerated with a good safety profile (13) .”

Patients considering taking CBD to treat their migraines may rest assured that the substance is not habit-forming. During a 2015 conference, Nora Volkow, MD , the director of the National Institute on Drug Abuse (NIDA), stated that CBD does not produce euphoria, intoxication, or addiction, unlike opioid medication (14) .

CBD has shown promise in relieving pain associated with migraines. According to Dr. Stephen Silberstein of the American Migraine Foundation and director of the Headache Center at Jefferson University Hospital in Philadelphia, CBD topicals are a viable option for patients who experience joint and muscle pain linked to migraines (15) .

Dr. Silberstein stated that taking CBD oil is reasonable among patients who experience a lot of neck pain or soreness. He also said that CBD oil may prevent vomiting and nausea. Some studies support Dr. Silberstein’s claims about CBD’s antiemetic properties.

In 2019 , a study in the British Journal of Pharmacology cited significant evidence that manipulating the endocannabinoid system regulates vomiting and nausea among humans and animals capable of vomiting in response to a toxic challenge (16) .

According to the study, preclinical research indicated that CBD and other cannabinoids are potentially useful in treating both vomiting and nausea caused by treatments, such as chemotherapy.

Meanwhile, a 2013 review in the European Journal of Pharmacology discusses the potential of utilizing cannabinoids in the regulation and treatment of debilitating conditions, specifically vomiting and nausea (17) .

The National Headache Foundation has also estimated that nearly 40 million people, or 12% of the United States population, are experiencing migraines (18) .

The organization further explains that the pain from migraine headaches results from signals interacting with blood vessels and the nerves surrounding the brain. Blood vessel nerves are activated when you experience a headache. This occurrence also results in the nerves sending pain signals to the brain.

The pain results from the swelling of blood vessels surrounding the nerve endings. This occurrence happens when overactive nerve cells send impulses to the blood vessels, causing the release of substances, including serotonin and prostaglandins.

Serotonin is a body chemical required by nerve cells and the brain to function, while prostaglandins are lipids that regulate blood flow and inflammation.

In 2005, researchers studied migraine as an inflammatory disorder (19) . CBD allegedly possesses anti-inflammatory properties, which can help with migraines related to inflammation.

The 2005 study published in the Neurology journal of the American Academy of Neurology explained that migraine is not usually associated with heat, redness, and swelling. As such, migraines are not traditionally classified as an inflammatory disease.

Years after , a 2017 study published in the Physiological Reviews journal of the American Physiological Society showed that intense sensory nerve stimulation might be partially responsible for the pain from migraine headaches. Inflammatory agents during a migraine attack cause this stimulation (20) .

Some studies support the purported anti-inflammatory properties of CBD. In particular, a 2018 study published in the Journal of Pharmacology and Experimental Therapeutics highlighted CBD’s potent anti-inflammatory properties (21) .

Meanwhile, a 2012 study noted how CBD inhibit ed neuropathic and inflammatory pain by targeting glycine receptors (22) . Glycine is an inhibitory neurotransmitter involved in the processing of motor and sensory information that allows movement, vision, and audition.

The study’s findings suggest that glycine assists cannabinoids in the suppression of chronic pain.

Although studies have documented CBD’s potential as an analgesic, CBD requires more longitudinal analysis to substantiate its purported benefits as a pain reliever against migraines.

Risks of Using CBD for Migraines

CBD oil companies marketing their products as dietary supplements or medicine for any condition is prohibited , according to the United States Food and Drug Administration (FDA) (23) . The FDA is responsible for ensuring the safety, efficacy, and security of drugs for human and animal patients to protect public health (24) .

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There is a lack of evidence on CBD as a viable treatment for migraines or other debilitating conditions, aside from the treatment of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome in children over the age of one .

The FDA has approved Epidiolex as a CBD treatment for children who experience seizures caused by rare and severe forms of epilepsy only . Epidiolex is the first FDA-approved narcotic that contains a pure, marijuana-derived drug substance (25) .

In terms of migraine treatment, researchers in 2017 conducted a review of related literature and noted a potentially useful role for medical cannabis in treating migraine. Unlike CBD products, medical cannabis may exceed the federally legal amount of 0.3% THC on a dry weight basis.

The review of studies is published in the Cannabis and Cannabinoid Research journal (26) .

Despite the collection of studies centering on the potential of medical cannabis in treating migraines, there is a lack of structured experiments on using CBD oil specifically for migraines.

In addition to the lack of CBD-specific research, migraine patients have different responses to existing modes of treatment (27) . The complex nature of migraines challenges researchers to define the exact criteria for future clinical assessments.

Although CBD has a good safety profile according to the WHO, CBD usage has shown potential side effects. Some of which include dry mouth, liver damage, changes in alertness, loss of appetite, gastrointestinal problems, mood swings, drowsiness, diarrhea, and fatigue (28) .

A 2017 research noted CBD’s potential to interact with other drugs that people with migraines may already be taking. Potential interactions with prescription medications may alter the body’s capacity to metabolize certain medications (29) .

Before turning to CBD to treat your migraine, you should also beware of getting scammed by unreliable CBD brands. Unlike some of the best CBD oil for migraines we have listed here, a 2017 review exposed inaccurate labeling in some CBD products.

Upon conducting laboratory analyses, the researchers noted that some product labels listed CBD contents that exceeded the actual amounts (30) .

Other risks include the presence of pesticides or other harmful substances. This finding highlights the need for CBD brands to be transparent with their CBD products’ third-party lab tests, including the item’s manufacturing processes to prove that it is pesticide – or GMO-free.

With these precautions, you can rest assured that you are investing in quality products.

How Soon Can CBD’s Effects in Migraines Be Felt?

Individuals with migraine may turn to CBD oil as a natural alternative to the over-the-counter (OTC) drugs they take to relieve headaches . However, currently, there is no substantial evidence of CBD as a migraine treatment.

Paracetamol, ibuprofen, and aspirin are common OTC painkillers and pharmaceuticals that reduce migraine symptoms. Meanwhile, you may seek a doctor’s recommendation to use triptans, which were developed specifically to treat acute migraine headaches (31) .

Paracetamol may need up to an hour upon ingestion to take effect (32) . Meanwhile, the time it takes for CBD to take effect may depend on the application method of your preferred CBD product format . There are multiple ways to use CBD oil for migraines.

CBD oil products may come in tincture (dropper) form, which patients can take sublingually . This method involves applying CBD oil under the tongue and waiting for about 90 seconds before swallowing the product.

The body absorbs CBD through the mucous membranes, so CBD avoids passing through the liver (33) .

Sublingual administration of CBD oil may take between 30 minutes to an hour before the user feels its effects. Once CBD takes effect after 60 minutes, you may continue to feel the results up to four to six hours after administration.

A 2010 study showed that peak blood levels, or the highest concentration of drugs in your bloodstream , of most substances taken sublingually are achieved within 10 to 15 minutes. Additionally, the sublingual application allows the body to absorb a more significant percentage of the dose compared to oral ingestion (34) .

Other ingestible forms of CBD include edibles, gummies, pills, and capsules. CBD food and drink products also come in different flavors, which people might prefer over the natural, earthy flavor of pure CBD oil.

A study noted that CBD remained in effect three to four hours after CBD was taken in capsule form (35) .

In 2018, authors of a study published in the Frontiers in Pharmacology journal suggested that consuming CBD orally after meals allow s for more efficient absorption of the compound (36) . They hypothesized that CBD’s highly lipophilic nature (state of being soluble in fats or lipids) enable s it to be easily dissolved in food’s fat content.

While such methods may be convenient for migraine patients turning to CBD for the first time, ingestible formats may take longer for patients to feel the purported pain relief effects of CBD as the body must digest the compound first.

CBD oil products also come in vape form, which you can inhale to avoid having the product go through the digestive system. Vaping may be the fastest method to get CBD into the body as the product enters the bloodstream through the lungs.

However, individuals who are considering vape for the first time must consult with a medical practitioner first . Vaping poses possible health issues, including chemical irritation or allergic reactions to various substances in the inhaled products (37) .

Meanwhile, topical CBD exists in the forms of lotions, salves, creams, transdermal patches, or massage oil. Topical administration of CBD is ideal for the effective treatment of inflammation in a specific body area. You can apply topicals directly to your painful body parts during a migraine attack.

Transdermal CBD with proper formulation may work instantly upon application, relieving patients of their pain within 15 minutes (38) . CBD topicals target localized cannabinoid clusters through the skin, meaning it does not have to interact with the ECS as a whole .

A 2016 study using a rat model noted the positive effects of CBD’s transdermal application in reducing inflammation and pain-related behaviors of arthritis (39) .

Some CBD brands may claim that their CBD products’ effects last up to 12 hours, which is questionable because of the current lack of longitudinal clinical trials to support CBD’s effects .

What Is the Dosage for Migraines?

Currently, there is no official recommended CBD dosing for migraines, high blood pressure, or any medical condition. Doctors with experience in cannabis use may offer medical advice and recommend that patients start with low doses to get the body acclimated to the substance slowly.

Users may then gradually increase their dosage until they experience the desired results. Still, determining the appropriate amount of CBD to take for migraines might be a trial-and-error process.

Other factors affecting CBD dosage may include the frequency of migraine attacks, the severity of migraine symptoms, age, and body chemistry. The CBD format may also affect the dosage.

For example, gummies or capsules may be easier to ingest as CBD comes in pre-measured doses . In contrast, CBD oil tinctures usually come with a dropper, which people can use to adjust the amount they intend to take.

Patients who live in a state where CBD products are legally available as OTC drugs in licensed dispensaries may look at the instructions listed on a CBD product’s label.

CBD manufacturers and brands are likely to have guidelines for doses printed on the product label, the accompanying paperwork, or the brand’s website.

Legality of CBD

Only 47 out of the 50 states in the USA (United States of America) have allowed the federally legal use of CBD with varying degrees of regulation per state (40) . Per federal laws, people may travel through the states with CBD, granted that the state they are coming from and traveling to have placed similar policies on CBD usage.

CBD’s legality in the US is typically associated with the Agriculture Improvement Act of 2018 or the 2018 Farm Bill (41) . This law declassified hemp plants as marijuana plants, thus removing them from the Schedule I category of the 1970 Federal Controlled Substances Act (42) .

Before the 2018 Farm Bill’s passage, both hemp and marijuana plants belonged under the Schedule I drugs category, which consist s of potentially addictive or abusive substances without any accepted health benefits.

The 2018 Farm Bill redefined hemp plants as cannabis plant varieties that contain less than 0.3% THC on a dry weight basis, while marijuana plants contain more THC than the established limit. CBD and THC may come from cannabis plant species, like Cannabis sativa .

Apart from the redefinition of hemp-based on its THC content, the 2018 Farm Bill granted the FDA permission to regulate CBD’s circulation on the market (43) . The agency reserves the right to penalize CBD companies that make unproven claims about the health benefits of CBD products.

CBD and THC are the most abundant cannabinoids in cannabis plants, meaning both compounds are present in both hemp and marijuana. The difference in THC concentrations implies that CBD oil from hemp does not have psychoactive effects.

THC’s psychoactive properties make people experience euphoria or get them high. Thus, this phenomenon plays a significant role in the legality of CBD products.

CBD oil within the legal limit of 0.3% THC does not produce a high in users and allows them to get the purported benefits of cannabis plants.

Since marijuana contains more than 0.3% THC, it remains in the Schedule I category of drugs with a high potential for abuse (44) . For this reason, CBD oil derived from marijuana plants is federally illegal in the US.

Only qualified patients with certifications from licensed healthcare providers may purchase CBD oil that exceeds the federal THC limit. These patients may apply for a medical marijuana card, which has varying qualifications depending on the state of their residence.

Despite federal laws, US states have their local laws on CBD and marijuana use.

While the 2018 Farm Bill removed legal restrictions on owning hemp-derived CBD products, local laws may supersede federal regulation s since the state is the primary enforcement authority for drug-related offenses (45) .

CBD Oil for Migraines: How to Apply CBD Oil for Headaches

If you suffer from migraines, there are two things that probably irritate you the most.

First — the debilitating migraine headache itself.

Second — your friends use the term “migraines” to talk about any headache they experience.

Seriously, if you’ve ever had a migraine attack, you’ll never compare it to a regular headache, even if you think it’s on the verge of being manageable. Migraines can prevent you from performing even the simplest tasks.

Migraines are a serious problem among women; 18% of women in the US suffer from regular migraines compared to 6% of men. And yet, despite the striking prevalence, we know very little about the cause of this condition and how to fight it.

After failing with conventional treatment methods, many people desperately turn to natural resources for help — such as CBD oil.

CBD oil may relieve pain and reduce inflammation, but recent research shows it’s also a potential anti-migraine agent.

In this article, I will highlight the top 5 CBD oil brands that may help you relieve migraine headaches and perhaps even prevent them from happening.

Of course, I’ll also take you on a journey through the science behind CBD and migraines, so let’s get started.

Top 10 Best CBD Oil for Migraines (Brand Recommendations 2022)

Buying CBD oil online is a hard nut to crack.

Most people don’t have the time to read about extraction methods, certificates of analysis, hemp source, and all the other factors that decide about the quality of CBD oil.

Some people just want straight answers — “that brand is awesome because…”

And that’s exactly where you’ll get your answers. Below I show you my top 5 brand recommendations for CBD oil and migraines.

1. Royal CBD (Best Migraine Reliever)

Get 15% off all Royal CBD products. Use code “CFAH” at checkout.


  • Their products are available as full-spectrum or “zero-THC”
  • Up to 83.3 mg of CBD per mL (2500mg bottle)
  • Every batch of product has been tested by independent labs
  • Their CBD is sourced from American-grown hemp
  • The natural flavor tastes great


  • The price is slightly higher than average (although this is well justified)

What I Like About Royal CBD:

Royal CBD is a premium CBD brand that offers a range of high-quality CBD products. They like to keep it simple; their assortment consists only of CBD oil, capsules, and gummies.

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I’ve been using their 1000mg CBD oil for quite a while now, and I must say I’m excited about how it works for my migraine headaches. Most of the time, when I have a migraine attack, I’m so debilitated that I can’t even move my finger, so taking CBD capsules or chewing on gummies is not an option.

With the oil, the experience is different because all I have to do is put a few drops under my tongue and wait for them to get absorbed while I’m lying on the couch and trying not to explode.

This full-spectrum CBD oil is pretty strong, so I’d recommend the 1000mg option to those with really severe migraine symptoms. At a lower cost, you can try their 250mg and 500mg bottles.

2. Gold Bee (Best Organic CBD Oil)

  • Unique product selection
  • Gold Bee uses non-GMO, Colorado-grown hemp
  • The oil contains full-spectrum CBD
  • The company’s products are extracted with CO2
  • You’re getting up to 2400 mg of CBD per bottle
  • The oil is sweetened with organic honey
  • Third-party lab tested for potency and purity
  • No high-strength oils
  • Not available in-store
What I Like About Gold Bee:

Gold Bee is a true maverick when it comes to CBD extracts. This California-based brand offers a unique selection of products, including full-spectrum CBD oil that is sweetened with organic honey and CBD-infused honey sticks for the flavor chasers. The entire product line up is sourced from organic hemp, extracted with CO2, and third-party lab tested for potency and purity.

I’ve been taking the 1200 mg kiwi flavor for prevention and to ease the migraine pain once it has kicked in. I’ve noticed similar results to what I’ve been getting with some more potent oils from competitor brands, which already tells much about the oil’s quality. The kiwi flavor also does a great job in masking the earthy aftertaste of full-spectrum CBD, and most importantly, both flavorings and the sweetener are all-natural.

Gold Bee offers a 30-day money-back guarantee for its products, allowing customers to return their products for a full refund if they decide they are not satisfied with the results; it’s a great sign of the brand’s confidence about their quality.

3. CBDPure (Runner Up)


  • Sourced from American-grown hemp
  • Tested for potency and purity in 3rd-party laboratories
  • Contains the full spectrum of cannabinoids and terpenes
  • You can return the product within 90 days for a full refund if you’re not satisfied with the product.


  • Narrow product range
  • Low potency

What I Like About CBDPure CBD Oil:

CBDPure is one of the most honest companies I’ve ever encountered. They give you a nice insight into each production stage of their CBD oils and prove their label claims with certificates of analysis from independent laboratories.

When it comes to migraines, I would use CBDPure oil as a preventative supplement to ease mild to moderate headaches, ones that aren’t caused by migraines.

These guys are keepers for those CBD users buying CBD on a budget, and if you end up not satisfied with the purchase, you can return the product within 90 days for a full refund.

4. Hemp Bombs


  • They have a diverse product range made from CBD isolates
  • Each batch is subject to third-party lab testing
  • Their products offer the highest dose of CBD per serving


  • The extracts used by Hemp Bombs are of lower quality than Royal CBD
  • CBD isolate doesn’t induce the entourage effect because it lacks other cannabinoids

What I Like About Hemp Bombs:

Hemp Bombs has one of the most diverse product ranges in the entire industry. They sell oils, topicals, edibles, vape oils, pet treats, CBD shots, and some really crazy products like CBD-infused beard lotions.

While the quality of their extracts is one class lower than the one offered by brands like Royal CBD, HempBombs makes great products for those who can’t use full-spectrum extracts for a variety of reasons (e.g., pregnancy or the risk of testing false positive on drug screening).

Because these products are made from 99.9% pure isolate, you need higher doses to achieve relief than with full-spectrum CBD oil. As such, I encourage you to opt for their higher potencies, as can have a better effect on you and turn out more cost-efficient in the long run.

5. CBDistillery


  • Their products are available as full-spectrum CBD or pure CBD oil (Zero THC)
  • Each batch of product is tested for potency and purity in a 3rd-party laboratory
  • Five strengths to choose from
  • Great price for the value


  • Their hemp isn’t organic
  • Their website doesn’t provide the best User Experience

What I Like About CBDistillery:

Here’s my top 3rd pick. There are two reasons why I decided not to give this brand a higher note — the way CBDistillery farms their hemp (the plants aren’t organic) and how their website gives me a heart attack every time I come back to see what’s new in their store.

On a positive note, I’d like to stress how much I love the fact they cater to every type of CBD user out there. CBDistillery sells their extracts as either “full-spectrum” or “pure oil.” On top of that, they ensure an outstanding potency range, starting at 250mg up to 5000mg of CBD per bottle.

6. NuLeaf Naturals


  • Their CBD comes from domestic hemp
  • NuLeaf obtains its extracts using a mix of subcritical and supercritical CO2
  • Each batch is lab-tested for potency and contaminants
  • Sold as full-spectrum extracts
  • Up to 4850mg of CBD per bottle


  • Narrow product range
  • More expensive than the other companies

What I Like About NuLeaf Naturals:

Another pioneer (next to CBDistillery), NuLeaf naturals sells full-spectrum CBD oil for humans and dogs.

The reason why I decided to keep them in this ranking is the fantastic choice of bottle sizes this brand offers — from 5mL to 100mL.

The potency in those sizes are the same, so your choice will depend on how frequently you use CBD oil and how long you need to supply yourself for.

These are full-spectrum extracts, so you gain the benefit of the entourage effect. However, for some reason, these oils are priced higher than all the brands in this ranking. That’s weird because there’s no extra value in their products — the hemp isn’t organic, and the formula is rather typical of most CBD oils.

7. Charlotte’s Web

Technical Details
Total CBD Content 200 – 1800 mg
Available Flavors Mint Chocolate, Lemon Twist, Orange Blossom, Olive Oil
Potency 7 – 60 mg/mL

About Charlotte’s Web:

Charlotte’s Web is one of the companies that blazed the trail for the CBD market as we know it today. Launched by the Stanley Brothers, the company has made big headlines in the mainstream media when they helped now late Charlotte Figi with her treatment-resistant epilepsy. Although the brand has recently received a warning letter from the FDA due to their health claims, they still have a reputation of a solid manufacturer.

The Charlotte’s Web CBD oil is available in 4 concentrations: 200 mg, 500 mg, 1500 mg, and 1800 mg of CBD per bottle. The strongest version comes with 60 mg of full-spectrum CBD in every milliliter. You can choose between two bottle sizes — 30 mL and 100 mL — and four flavor options, including Olive Oil, Mint Chocolate, Lemon Twist, and Orange Blossom.

What could Charlotte’s Web do better?

Well, for starters, they could switch from ethanol extraction to CO2 extraction because such products have a better chemical profile and are more efficient in terms of production. Secondly, and more importantly, I’d like to see these CBD oils suspended in MCT oil because suspension in olive oil makes them taste a bit too bitter for my palate — even in the flavored variants.


  • One of the most reputable brands on the market
  • Full-spectrum CBD
  • Delicious flavored versions
  • Up to 1800 mg of CBD per bottle
  • Available in two sizes: 30 mL and 100 mL
  • Third-party tested for potency and purity


  • Non-organic hemp
  • Ethanol extraction
  • Suspension in olive oil (bitter taste)
  • The company received a warning letter from the FDA in the past due to inappropriate health claims

8. cbdMD

Technical Details
Total CBD Content 300 – 7500 mg
Available Flavors Natural, Berry, Orange, Mint
Potency 10 – 250 mg/mL

About cbdMD:

cbdMD is another well-known brand that sells an array of CBD extracts, including tinctures, capsules, gummies, sleep aids, topicals, bath bombs, and pet products.

The company offers a broad range of CBD oils, with up to 7500 mg of CBD per bottle. The strongest version packs a healthy dose of 200 mg of broad-spectrum CBD suspended in MCT oil for better absorption and a smoother flavor. These oils are available in three flavored options: Berry, Orange, and Mint.

The lack of the trace amounts of THC makes cbdMD products suitable for younger users, athletes, and people who are regularly tested for THC at work. But on the other hand, broad-spectrum CBD doesn’t evoke the full entourage effect. The effects of CBD aren’t linear on the dose-response curve, so higher concentrations may not translate into better results in this case.

CbdMD also has high transparency standards. All of their products are tested by a third-party laboratory; the batch-specific certificates of analysis are available on the cbdMD’s website.

cbdMD is another popular manufacturer that offers a wide range of CBD extracts, from tinctures to cummies to capsules, bath bombs, topicals, sleep aids, and pet products.


  • US-grown, non-GMO hemp
  • CO2 extraction
  • THC-free
  • Up to 7500 mg of CBD per bottle
  • Batch-specific certificates of analysis


  • Limited entourage effect due to the lack of THC
  • Most people don’t need such high doses of CBD in their routine

9. Medterra

Technical Details
Total CBD Content 500 – 3000 mg
Available Flavors Natural, Citrus, Mint Chocolate
Potency 16 – 100 mg/mL

About Medterra:

Medterra is a small artisan brand rooted in California. The company specializes in premium CBD oils in various cannabinoid spectra, including full-spectrum CBD, broad-spectrum CBD, and CBD isolate. These products contain from 500 mg to 3000 mg of CBD per bottle, which is a regular range for CBD companies. Aside from the unflavored version, you can choose from two flavored options: Citrus and Chocolate.

The company prides itself on making real full-spectrum CBD, with 2 mg of THC in each bottle. However, the problem with these extracts is that they’re not legal in all 50 states. So, if you want to purchase their products legally, your options are limited to broad-spectrum CBD and CBD isolate. On the other hand, these products contain upwards of 1000 mg of CBD, which may appeal to those who benefit from higher doses in their routine.

Medterra’s products are tested in a n independent laboratory for their CBD content and safety.


  • Premium-grade CBD oils
  • Up to 3000 mg of CBD per bottle
  • Available as full-spectrum CBD, broad-spectrum CBD, and isolates
  • Lab tested for potency and purity


  • The “real” full-spectrum CBD oil isn’t available in all states
  • Some of the lab reports indicate higher CBD levels than stated on the bottle
  • No discounts for returning customers

10. Joy Organics

Technical Details
Total CBD Content 450 – 900 mg
Available Flavors Tranquil Mint, Fresh Lime, Summer Lemon
Potency 15 – 30 mg/mL

About Joy Organics:

Joy Organics is one of the most well-known brands in the CBD space. The company was founded by a woman named Joy Smith, who has been using hemp extracts to manage her problems with pain and sleep. After reaping the benefits of CBD herself, she has decided to share her passion for CBD oils with other people seeking natural and safe alternatives to conventional treatments.

The company offers a range of broad-spectrum CBD oils from certified organic hemp. They have a lot of positive reviews all over the internet; they also haven’t received any warning letter from the FDA regarding health claims or other ‘unfair’ practices.

Joy Organics focuses on broad-spectrum CBD formulations in a low potency range — from 450 to 900 mg of CBD per bottle. The stronger version features 30 mg of CBD per milliliter, which is a standard dose among daily users who use this product as a means of supplementation. These are one of the tastiest CBD oils I’ve tried to date; you can choose from three refreshing flavors: Fresh Lime, Tranquil Mint, and Summer Lemon.

In 2018, one of the company’s flavored CBD oils was found to be contaminated with a fungicide that is commonly sprayed on citrus fruits. Fortunately, Joy Organics has quickly fixed the problem by removing the flawed product batch and implementing new third-party testing systems to make sure such mistakes won’t happen again.

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  • Non-GMO, US-grown hemp
  • Supercritical CO2 extraction
  • Broad-spectrum CBD
  • THC-free
  • Delicious flavors


  • A bit expensive
  • No high-strength oils

What Are Migraines?

Migraines are severe headaches that can last for anywhere between 4–72 hours. They are perceived as a throbbing sensation usually affecting one side of the head.

Most often, it feels as if someone was trying to squeeze your skull while pounding it with a hammer at the same time.

Nothing enjoyable, to say the least.

Aside from the unbearable pain, migraines can also trigger other symptoms such as nausea or vomiting, and sensitivity to light and sound.

Migraine headaches affect more than 38 million people within the US alone. Women are three times as likely to suffer from migraines as men.

Migraines come in two distinct forms: with or without aura.

The vast majority of people (70–90%) experience migraines without aura. This type lasts between 4–72 hours and is accompanied by pulsating pain on one side of the head.

Migraine with aura is another common type that derives from neurological symptoms triggered by the headache. These symptoms include tunnel vision, flashing lights, and colored spots in the eyes, as well as blind spots in the field of vision.

Migraines can be both acute and chronic; chronic migraine lasts even 15 days in a month.

Scientists are still trying to figure out the exact cause of migraine headaches, but they believe them to result from alterations of chemicals, nerves, and blood vessels in the brain.

Common Migraine Treatment Options

If your migraines aren’t severe and result mostly from environmental triggers, you can learn to avoid them and thus reduce their frequency.

Consider using the following techniques:

  • Stress management (behavioral therapy)
  • Taking care of your sleep quality
  • Avoiding allergens and bright lights

When these methods fail to deliver expected results, your physician will recommend one of the conventional treatment options.

Acknowledged migraine treatments include:

  • Over-the-counter (OTC) painkillers like acetaminophen
  • Nonsteroidal anti-inflammatory drugs (e.g., ibuprofen or aspirin)
  • A combination of medicines that mix pain relievers and caffeine
  • Anti-migraine prescription drugs, such as antidepressants, seizure medications, and beta-blockers
  • Botox treatment

No treatment works for everyone, but some of these methods can reduce the frequency of migraine headaches and dampen the intensity once they start.

However, when absolutely none of the above methods relieves you from migraines, CBD oil may be your last hope.

Does CBD Help with Migraines?

CBD stands for cannabidiol and is one of the 400+ compounds found in the cannabis plant. It’s the most abundant cannabinoid along with THC, but unlike THC, it has no psychoactive properties, meaning it won’t get you high.

CBD is a modulator to the endocannabinoid system (ECS). It acts on the two sets of cannabinoid receptors (CB1 and CB2) to help the ECS maintain the chemical balance in the body and brain.

In essence, CBD signals these receptors to produce more of the body’s own cannabinoids and makes them more available for the body by blocking the enzyme responsible for their breakdown.

Studies have shown that CBD can work as a painkiller, anti-inflammatory, antioxidant, and neuroprotectant, hence the impressive number of its health benefits.

But how could CBD help with migraines? To answer that question, we need to examine the relationship between CBD and the endocannabinoid system closely.

Why Would CBD Oil Work for Migraines?

Although the research in this area is still in its infancy — mainly due to the federal restrictions on cannabis and its molecules until recently — there are some indications that CBD may assist migraine attacks or intense headaches.

Migraines & the Endocannabinoid System

The endocannabinoid system has been proposed as a significant factor when it comes to migraines and its management through CBD administration.

According to a study published in the Journal Experimental Neurology, this system may be centrally and peripherally engaged in pain signaling. This may be caused by the endocannabinoids’ ability to inhibit the release of neurotransmitters responsible for perceiving pain via interaction with the CB1 receptor in the brain.

The authors of the paper suggest that the endocannabinoid system is where migraines may have their roots, and that CBD could serve as a promising tool for alleviating the physiological and inflammatory aspects of pain that are involved in migraine headaches.

CBD, Anandamide, and Migraines

If this theory proves accurate, then the lack of endocannabinoids within the ECS may just as well be a contributor to migraines. This condition, which is officially described as clinical endocannabinoid deficiency, could be the cause of migraine headaches in many people.

Anandamide (or AEA), one of several endocannabinoids produced by the human body, has the ability to both increase and decrease the activity of serotonin receptors. A paper from Neurology Letters suggests that this feature can have therapeutic applications within the domain of migraines. Anandamide has also been shown to be tonically active within the gray matter of the brain, which is responsible for migraine generation.

Another research published in the Journal of Headache and Pain has investigated the role of AEA administration with animal models. The study confirmed that a compromised endocannabinoid system might cause the development of migraine attacks. The authors of the paper suggest that modulation of CB1 and CB2 receptors can be useful in the treatment of migraines.

CBD can manipulate AEA levels within the body and maintain its adequate concentrations in the brain, hence its potential to relieve migraine pain.

How to Use CBD Oil for Migraines?

There are several ways to use CBD oil for migraines. Each of the methods I describe in this section provides a slightly different type and duration of effects.


You can inhale CBD oil or concentrates for migraine relief. The healthiest and easiest method of inhaling CBD is vaporization, which means heating the CBD vape oil in a device called a vaporizer.

Vaporization only heats the material to the point where it releases CBD-rich vapor. You then inhale through the vaporizer’s mouthpiece.

Since there’s no combustion, vaping CBD oil doesn’t deliver harmful substances to your system.

But most importantly, vaporization has the highest bioavailability of all consumption methods. In other words, vaped CBD delivers more of the active substances than sublingual or oral CBD.

Research has shown that the bioavailability of vaporized cannabidiol ranges between 35–56%, which is about 1.5 times as much as sublingual products and 10–14 times as much as edibles.

Sublingual Drops

In its most common form, CBD is applied sublingually. Once you measure out the necessary amount of CBD oil with a dropper, you squeeze the dose under your tongue and wait until it gets absorbed through a special membrane.

From there, CBD travels straight to the bloodstream. This helps the user to avoid the “first-pass effect” because cannabidiol doesn’t have to be processed by the liver. Usually, the ad hoc effects become noticeable after 20–30 minutes.

Sublingual CBD is a good option to consider for those migraine sufferers who want to steer clear of additives like propylene glycol or vegetable glycerin, which are present in CBD vape oils.


Although CBD topicals offer the lowest bioavailability, they can be a viable option for fighting localized pain. Not only that, but topical products also soothe the nerves in your head that release Calcitonin Gene-related Peptide (CGRP) — a peptide that has been scientifically proven to trigger migraine headaches.

It turns out that chronic migraine sufferers have high levels of CGRP and low levels of endocannabinoids. According to a study published in the European Journal of Pain, topical CBD can reduce CGRP, inflammation, swelling, and pain in animal arthritis.

Potential Risks & Side Effects

Just as any health supplement, CBD oil can cause some side effects. However, these side effects are relatively minor and don’t put your health or life in danger — as long as you buy high-quality CBD oil from a trusted manufacturer.

That’s why people use it so eagerly.

The only side effects that may appear when you take too much CBD oil is dry mouth, lowered blood pressure, and dizziness. Rare cases include examples of diarrhea after consuming extremely high doses of CBD.

CBD blocks the enzyme in the liver that is responsible for processing drugs; given this, taking CBD oil along with many medicines may lead to increasing the concentration of these drugs in your system and cause “second-hand” side effects (not related to using CBD on its own).

That being said, it’s important that you talk to your doctor prior to buying CBD oil if you take any other medications it could potentially interact with.

Things to Do Before You Decide to Buy CBD Oil from Any Company

Buying CBD oil is an investment in your well-being, but as with any investment, you shouldn’t act on the spur of the moment.

When browsing through different brands and products, make sure you don’t miss out on any of the following points:

Ask for Lab Reports from 3rd-party Testing

Lab analysis will tell you everything about CBD oil, from its CBD potency to the cannabinoid profile and terpenes to potential pollutants.

Every company has the option to submit a sample of their product to a third-party laboratory for examination. If there are any inconsistencies in the potency, or the product turns out contaminated, the lab test will detect it.

Therefore, if a company isn’t honest about how they test their CBD oil and they don’t show lab reports anywhere on their website — even on request — that’s an instant red light.

Choose the Right Potency

The potency of CBD oil is measured in milligrams of CBD per one milliliter of the liquid. Lower potencies are designed rather for preventive supplementation or to fight mild symptoms, so options like 100mg or 250mg of CBD will suit you if you’re new to CBD oil or if you suffer from headaches caused by weather or changes in pressure.

On the other hand, if your migraine symptoms are on the verge of manageable and you’ve used up other resources, then opt for potencies of 1000mg and up — preferably with the full spectrum of cannabinoids.

Which brings us to the next point.

Opt for Full-spectrum CBD Extracts

Full-spectrum CBD oil contains all cannabinoids, terpenes, and other phytonutrients from hemp.

Research shows there’s a unique synergy between cannabinoids and terpenes which greatly increases their effects — this concept is known as the entourage effect. Simply put, the aforementioned compounds are more effective together than each of them in isolation.

Studies suggest that full-spectrum extracts are superior to isolates in easing pain and inflammation, both of which affect migraine sufferers.

CBD Oil for Migraines: Can It Really Help?

While the research on CBD and migraines is in its early stages, what we already know is that this cannabinoid may be a potent anti-migraine agent with some potential to reduce or even eliminate migraine headaches for good.

If the theory that migraines are caused by endocannabinoid deficiencies finds confirmation in clinical human studies, we may finally find an effective tool for easing the symptoms of this painful condition and fixing the problem at its roots.

I hope this article has helped you understand the apparent relationship between the CBD, the endocannabinoid system, and migraines — and that you’ll find the best CBD oil to relieve yourself from that crippling pain.

What’s your experience with using CBD oil for migraines?

  1. Greco, R., Gasperi, B., Maccarrone, M. & Tassorelli C. (2010) The Endocannabinoid System and Migraine. Experimental Neurology, 224(1), 85–91.
  2. Russo, E.B. (2008) Clinical Endocannabinoid Deficiency (CECD): Can This Concept Explain Therapeutic Benefits of Cannabis in Migraine, Fibromyalgia, Irritable Bowel Syndrome and Other Treatment-resistant Conditions? Neuroendocrinology Letters, 29(2), 192–200.
  3. Greco, R., Mangione A.S., Sandrini, G., Maccarrone, M., Nappi, G., Tassorelli, C. (2011). Effects of Anandamide in Migraine: Data from an Animal Model. The Journal of Headache and Pain, 12(2), 177–183.
  4. De Petrocellis, L., Di Marzo, V. (2010). Non-CB1, non-CB2 Receptors for Endocannabinoids, Plant Cannabinoids, and Synthetic Cannabimimetics: Focus on G-protein-coupled Receptors and Transient Receptor Potential Channels. Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology, 5(1), 103–121.
Nina Julia

Nina created following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

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