What Are the Benefits of CBD for Multiple Sclerosis?
Research on CBD for MS is limited, but shows it might reduce pain and spasticity
Kelly Burch is a freelance journalist who has covered health topics for more than 10 years. Her writing has appeared in The Washington Post, The Chicago Tribune, and more.
Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more.
Emily Dashiell, ND, is a licensed naturopathic doctor who has worked in group and private practice settings over the last 15 years. She is in private practice in Santa Monica, California.
Multiple sclerosis (MS) is an autoimmune disease that causes a range of symptoms, including fatigue, cognitive impairment, and muscle weakness. MS can manifest in many ways, but patients have one thing in common: the symptoms of MS have a big impact on their quality of life.
To manage symptoms, some MS patients turn to cannabidiol, or CBD, a non-psychoactive compound found in the cannabis plant. Scientists are still researching the benefits of CBD for people with MS, but early indications show that CBD might help control some MS symptoms, such as pain and muscle stiffness.
This article will review what you should know about CBD and multiple sclerosis, including the potential benefits, safety concerns, and optimal dosage.
Verywell / Michela Buttignol
Immune System and Multiple Sclerosis
Multiple sclerosis is an autoimmune disease. That means that the symptoms of the disease occur because the immune system is attacking healthy cells in the way that it’s supposed to attack viruses and other pathogens.
In MS, the immune system targets the myelin sheath, a protective coating that wraps around nerve cells in the spinal cord and brain. When the immune system attacks this barrier, it causes inflammation and damage, which can impair the nerve signaling that facilitates movement, breathing, thinking, and more.
The severity of MS symptoms varies, depending on the location of the attack and the extent of the damage to the myelin sheath, but they most often include fatigue, muscle weakness or stiffness, and cognitive dysfunction.
Cannabinoids and the Immune System
Cannabinoids are a group of compounds found in the cannabis plant. The two main cannabinoids are THC (the psychoactive ingredients in marijuana) and CBD (which does not have a psychoactive component).
The body processes cannabinoids via cannabinoid receptors, which are found in the brain and in immune cells. This is all part of the endocannabinoid system, which regulates inflammation, immune function, motor control, pain, and other bodily functions commonly affected by MS.
This connection helps explain why CBD can be beneficial for MS. Cannabinoids have been shown to reduce inflammation and regulate immune response. CBD does this without mind-altering properties, making it appealing to people looking for relief from MS symptoms without the “high” of marijuana.
Benefits of CBD for MS
In a recent meta-analysis, researchers concluded that cannabinoids, including CBD, are “probably effective” at alleviating certain symptoms of MS, including pain and abnormal muscle tightness (spasticity), but “probably not effective” for treating muscle tremors or incontinence.
Additional research supported using CBD for MS. Here are some key findings:
- A 2018 scientific review found that CBD supplementation reduced pain, fatigue, inflammation, depression, and spasticity in people with MS, while improving mobility. The authors concluded that recommending CBD supplementation for people with MS would be advisable.
- A 2014 scientific review found that Sativex (nabiximols), a CBD nasal spray, can help reduce pain, spasticity, and frequent urination in patients with MS.
- Two different 2021 medical reviews found that in animal models, CBD helps regulate the immune system, reducing the autoimmune response that causes MS symptoms. More research is needed, but in the future this may mean that cannabis-derived medications and CBD could be used to treat the progression of MS, not just the symptoms.
Are There Any Side Effects?
CBD is generally considered safe, and it does not have mind-altering properties. A dose of up to 300 mg daily of CBD is safe for up to six months. Higher doses are safe for a shorter amount of time.
However, like any other supplements or medication, CBD may have side effects in some individuals. These may include:
- Low blood pressure
- Damage to the liver
In addition, CBD may interact with many other prescription drugs. It’s best to speak with your healthcare provider before supplementing with CBD, especially if you are pregnant or breastfeeding. Most doctors who treat MS are familiar with CBD, since at least 20% of MS patients are currently using CBD.
CBD is legal for consumption in the United States, but cannabis products that contain THC are illegal at the federal level. Be sure to understand the legal and professional implications of using CBD, especially if you are regularly screened for drug use.
Keep in mind that the Food and Drug Administration does not oversee or regulate any CBD supplements, so it’s important to purchase CBD products from a reputable source.
How to Use CBD for MS
CBD is available in many different forms, including topicals, tinctures, edibles, and nasal sprays.
You’ll also have to decide whether you want to take a full or broad-spectrum CBD, which contains other cannabinoids, or a CBD isolate, which contains just cannabidiol. Limited research suggests there may be a benefit to the “entourage effect”: It’s believed that having other cannabinoids present may make CBD more effective.
Consulting your healthcare provider can help you decide where to start with CBD supplementation. They can offer insight as to what has worked for other patients and guide you toward an appropriate dose of CBD.
How to Buy CBD for MS
It’s important to deal with reputable dispensaries when purchasing CBD for MS. Here’s what you should consider when buying CBD to treat MS:
- The legal status of CBD in your state, including whether you need a medical cannabis card
- The possible impact of taking CBD on your professional licenses or other areas in your life
- Your goals in taking CBD, and the symptoms you would most like to address
- Whether you would like a CBD isolate or a full-spectrum product that contains other cannabinoids
- Whether the retailer is licensed in your state
- Where the product was sourced (grown)
- Whether the product has a COA, or certificate of analysis, which shows the chemical composition of a substance
A Word from Verywell
MS can have a huge impact on your quality of life, which is why so many people look for relief from MS symptoms. The research around CBD and MS is very promising: It shows that some people experience reduced pain and spasticity when they use CBD supplements.
In the future, CBD-derived medication may even be used to control the progression of the disease by reducing inflammation.
Unfortunately, use of CBD for MS is still in its infancy, and there’s a clear need for more research. For now, it’s best to talk with your doctor and trusted peers when deciding whether CBD is right for you. Don’t be shy about speaking up: Research has shown that up to 60% of MS patients are currently using cannabis and 90% would consider it.
You shouldn’t feel any shame or hesitation about investigating this treatment option. However, it’s important to understand any legal and professional implications for where you live, especially if you use a product containing THC.
Although there is a lot of promise for CBD to treat MS, there is no FDA-approved treatment. Using it in combination with more traditional medically sanctioned treatment is likely a good course of action.
Frequently Asked Questions
Research indicates that CBD likely helps with muscle spasticity in people with MS. A UK-based study found that physicians did not measure a large improvement in spasticity in people taking CBD versus a supplement. However, the people taking CBD reported a reduction in spasticity compared with those taking a placebo. Because of that, the Multiple Sclerosis Society says that CBD is likely effective for spasticity.
CBD is generally considered safe, and some research shows that it likely helps treat pain and spasticity caused by MS. However, CBD is not FDA approved for treating MS or its symptoms. You should speak with your healthcare provider about using CBD to treat MS.
Much of the research on using CBD for MS pain has been done using oral supplements and nasal sprays. Some people also report benefits from smoking CBD flowers or cannabis. It’s best to speak with your healthcare provider and consider the legal standing of CBD and cannabis in your state as you decide how best to use CBD to treat MS pain.
Best CBD:THC Ratio For Multiple Sclerosis
There’s no cure for MS, but CBD & THC may be able to help.
Learn how to use CBD & THC & discover which ratio is best for MS symptoms.
CBD and THC work together to reduce neuropathic pain and spasticity in people with multiple sclerosis (MS).
A CBD:THC ratio with equal parts CBD to THC may help with a few of the side effects of MS. Between the entourage effect and the benefits of both CBD and THC for MS, the combination of both CBD and THC increases efficacy and amplifies pain relief.
Here’s what you need to know about taking CBD:THC ratio products for MS.
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Benefits of CBD & THC Ratios For Multiple Sclerosis
Multiple sclerosis, or MS, is caused by intense nerve damage, muscle weakness, and chronic pain in patients. CBD and THC are effective treatments for both relieving MS pain and reducing muscle spasms that cause further discomfort.
A 1:1 ratio of CBD:THC has shown in multiple studies to reduce spasticity in MS patients .
While the CBD works to reduce inflammation, calm your muscles, and relax your nervous system, the THC relaxes muscular tissue and relieves pain.
CBD and THC are helpful for MS patients in more ways than one. You can also use CBD:THC ratio products to improve your sleep, get longer rest, and ease neuropathic pain during the night .
The pain associated with MS is often due to nerve damage, which has been treated with CBD and THC in many clinical trials. CBD is believed to interact with the α3-glycine receptors, which determine how we feel pain, to reduce inflammation that causes neuropathic pain .
While CBD alone may be an effective treatment for MS muscle spasms, combining it with THC gives you further relief and harnesses the entourage effect.
The entourage effect is the phenomenon where CBD, and other cannabinoids, are more efficient and effective when accompanied by other cannabinoids that naturally occur in cannabis plants.
When you take CBD and THC together, you give both compounds the utmost chance of performing well, maximizing your pain relief and easing your spasms all at once.
How CBD & THC Compare To Other MS Medications
Living with MS is challenging not just because of the pain, loss of vision, fatigue, and related symptoms. It’s also a challenging diagnosis because the treatments often come with a host of side effects.
MS is commonly treated with chemotherapy, steroids, and immunosuppressive drugs. We certainly aren’t advocating for using CBD or THC to treat your MS in place of the medications your doctor has prescribed you.
However, CBD and THC can effectively mitigate some of the side effects of those medications while also offering you pain relief and an evidenced reduction in spasticity. If you experience nausea, loss of appetite, or pain due to your other MS medications, CBD and THC may be able to help.
Make sure to always ask your doctor about potential interactions with other medications.
Best CBD:THC Ratio For MS & How To Dose
The best CBD:THC ratio for MS is 1:1, meaning equal parts CBD to THC. While you can up the CBD or THC in this ratio to fit your needs, it’s important to get a healthy dose of both compounds.
To dose your CBD:THC ratio, decide how strong you want your CBD dose to be. Then, use our dosage calculator to figure out the mg of CBD to take. Simply match it with the same mg of THC.
Most studies recommend treating MS with oral CBD and THC products, like gummies, oils, or sprays. If you live in a state where medical marijuana is legalized, it’s easy to find 1:1 ratio products at medical dispensaries.
use our dosage calculator to determine how much CBD you should take based on your weight and desired strength
Other CBD:THC Ratios
CBD and THC ratios are being explored in different combinations for a host of different symptoms and health conditions.
Even pharmaceutical companies like GW Pharma have entered the market with their own proprietary mixes of CBD and THC.
Here are some of the best CBD to THC ratios for managing or supporting various health conditions based on the current evidence available today:
Here are some of the other ratios to consider based on the current evidence available:
— 1:10 — 1:1
- Best CBD:THC Ratio for Fibromyalgia — 1:1, 2:1, or 3:1
- Best CBD:THC Ratio for Anxiety — 1:1
- Best CBD:THC Ratio for Neuropathy — 1:1
Final Thoughts: Best CBD:THC Ratio For MS
The best CBD:THC ratio for MS is 1:1, meaning equal parts CBD to THC.
This lets you harness the spasticity reduction from the CBD and get pain relief from the THC. You can also enjoy the entourage effect by taking these compounds together.
The combination of CBD and THC has shown clear reduction in muscle spasms, neuropathic pain, and sleep in patients with MS and other nerve-related disorders. It may even help you cope with the side effects of your other MS treatments.