Does cbd oil for dogs interact with any medications

Can Dogs or Cats On Medication Take Hemp Oil?

First things first, hemp oil is completely safe for your dogs, even good for them! However, when mixed with certain medications it may cause a drug interaction.

Most of the time Hemp oil can be given to your dogs along with other prescriptions drugs, but that’s not always the case.

This article will explore further when hemp oil is ok to be mixed with medication and what happens when certain drugs mix with hemp oil.

How Does H emp Oil Interact With Other Prescribed Medications?

If your dog is on prescribed medication, when they take hemp oil it can, in fact, interact with the drug. This then affects a specific group of liver enzymes known as cytochrome P450.

Without sounding too technical this particular group of enzymes is known to metabolize more than half of the prescribed medications on the market today, such as ibuprofen, diazepam and amitriptyline.

Let’s break this down as simply as possible, so enzyme P450 works by adding oxygen to the medication, this makes it water-soluble and makes it easier for the kidneys to break it down.

When you add hemp oil to the mix, it may potentially inhibit the enzymes, therefore altering the liver’s capabilities of metabolic functioning.

In a nutshell, if the hemp oil and the prescribed medication are ingested at the same time, the enzymes will only really be able to break down one of the two.

This will generally leave the prescribed medication in the body longer, leading to a more significant effect of the drug.

Bear in mind that dosage plays a big part in this interaction. A little bit of hemp oil in combination with prescribed medication will likely not have a significant effect on your dog.

So you’re probably wondering now, which medication can interact?

What Medication Can Interact With H emp Products For Pets

As we’ve already mentioned this drug interaction only happens when mixed with certain medications, not all! The enzymes can metabolize more than half of the pharmaceutically prescribed medications on the market but the other half is uncertain.

To make sure, check out the list below of known medicines that have a possibility of interacting with hemp products when given in high dosages:

  • Antihistamines
  • Steroids
  • Benzodiazepines
  • Fentanyl
  • Narcotics
  • Anaesthetics
  • Antibiotics

What Health Benefits Does Hemp Oil Have For Dogs?

Although there is always a potential for drug interactions when you combine hemp products with medication, keep in mind that hemp oil has amazing benefits and can even diminish the use of harsh chemical drugs and be used instead!

It’s a natural, safe solution and helps with a lot of problems dogs have, including:

  • Allergies
  • Anxiety/Nervous Behaviour
  • Separation Anxiety
  • Arthritis/Joint Pain
  • Controls Seizures

When used with a combination of natural ingredients it can also help with dry, itchy skin, dry paws and noses, hot spots, eczema, psoriasis.

Using H emp Oil With Medication For Dogs

If you’re unsure whether the medication your dog/cat is on then get in touch with your vet. It can be really hard to judge what’s the best decision to make for your fur babies!

Unfortunately, sometimes medication can take up to 3 months to get into your pet’s system so you can be waiting a while for results. H emp oil works a lot faster than that, and you should see results in weeks, if not days, depending on what you’re using it for.

Monty’s Story Combining Hemp With Prescribed Seizure Medication

Monty is an English Springer Spaniel, aged 5. Superfit and healthy with no health issues, he suddenly had a fit one day which leads onto having a series of fits over the next few months and developing epilepsy.

After his first 4 fits, he was put on Phenobarbital which is an anti-seizure medication, after weeks of more seizures, that were strong and too frequent, the dosage kept getting upped and Potassium Bromide was added.

At his peak, Monty was on 8 tablets a day and the seizures weren’t even under full control, he consistently had a fit every 11 days. This didn’t sit right with his owner, Monty had become extremely anxious, developed separation anxiety and his behaviour completely changed. He was a different dog.

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This broke his owner’s hearts so they looked for another option. After finding us and trying our hemp Oil, Monty has never had a fit since, and all his anxieties are gone.

His owner informed the vet of this success and they are now month by month slowly reducing the medication. (it has to be done so slowly because it’s so strong).

To control seizures it is recommended to give a larger dose of hemp oil, however in this situation the medication is still involved. Although it’s safe to use hemp oil with the medication he’s on, he doesn’t need the full dose of hemp at this stage.

To read more about dogs with epilepsy or dogs that have seizures, click here.

His owners end goal is to rely solely on hemp oil and for Monty to be on no medication. Here’s a note from Monty’s owner, Olivia:

“Having Monty on so much medication didn’t feel right, especially as it wasn’t solving the problem. I’ve never had to have a dog on this much medication so looked for an alternative option as soon as I could.

I can’t even express how thankful I am to have found this company and for their amazing hemp oil. It has honestly saved my dog, I only wish I knew of it before I even went to the vets and never started him on medication. We had to wait 3 months for the one drug to take effect and are now having it to reduce it a pill at a time each month.

I’m so glad he’s happy and back to his old self, he used to have a fit every 11 days on medication alone which was so heartbreaking to see, it really knocked him about and he lost all confidence.

Since he’s been having hemp oil he’s not had one fit, all his anxieties are gone, he’s back to his old cheeky loving self. It’s now been 100 days since his last fit, which is just amazing!! Can’t recommend hemp oil enough, honestly, it’s saved my dog and in turn, saved me”

If you have a success story to share with us then please get in touch!


Hemp oil is a safe and natural supplement that be used alongside some medications and interact with others. Hopefully, this blog has made it clear which drugs to avoid using large doses of hemp oil with. Remember if you’re not sure always ask your vet or a specialist.

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Can my Dog take CBD Oil While Taking Other Medications?

With the pet CBD market industry exploding globally, it’s no surprise that we need to look out for any drug interactions. What many people don’t know is that dog CBD oil can interact with other medications by either enhancing the effect, or by interfering with the metabolism of some.

In this blog, we’ll discuss why it’s important to consult with your veterinarian first before using CBD pet products.

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Not only is this important so that you can get a proper diagnosis for a medical condition, but your veterinarian will be able to discuss any possible side effects if CBD is used together with other pet meds.

Here’s what you need to know to fully protect your pet, and to make sure that there are no drug interactions.

CBD can alter the way your dog processes certain medications

Yes, although cannabidiol (CBD) is a natural supplement that is beneficial for numerous health conditions in pets, as well as for chronic pain, insomnia, depression , and anxiety, CBD does have the potential to interact with certain medications.

CBD is derived from the hemp plant, yet it can also come from the marijuana plant. CBD hardly ever contains delta-9-tetrahydrocannabinol (THC), which is the compound that gives marijuana its “high” effect. High-quality CBD is non-toxic and considered safe for pets and humans alike.

There are almost no side-effects, apart from those coming from a low-quality CBD oil that may contain contaminants. It’s always best to look out for the compromised quality of some CBD oils.

You’ll need to discuss with your veterinarian all supplements, over-the-counter meds and prescription meds that your pet may be taking. Today research continues to demonstrate how effective CBD oil is for pets, yet one still needs to examine how it can interfere with the metabolism of pet meds and other supplements.

Benefits of CBD Oil for Dogs

Cannabidiol (CBD) extract is quickly gaining popularity as a natural alternative for managing pain, inflammation, and a variety of medical conditions, including epilepsy. However, recent reports have called into question the safety of CBD when used together with other pet meds. It’s also good to note that using a compromised quality or low-quality CBD oil raises the risk of side effects.

A recent 2019 study by the University of Korea, demonstrates that the CBD anti-cancer protein shows potential in killing tumor cells. The researchers tested the synergistic effect of CBD with a cancer destroying protein called TRAIL. (TNF related apoptosis- inducing ligand.)

The study concluded that TRAIL and CBD created apoptosis separately in colorectal cancer cells. The researchers also found that together, both reduced cancer cells a lot. “ To the best of our knowledge,” they wrote, “this is the first report that cannabidiol induces significant TRAIL-induced apoptosis of colorectal cancer cells,” noting that earlier reports suggested that a different protein response was responsible for cancer-cell death.” via MDPI Journals.


The FDA has also tested the chemical content of cannabinoid compounds in some of the products, and many were found to not contain the levels of CBD they claimed to have. We have also heard reports of CBD potentially containing contaminants (e.g., pesticides, heavy metals); we are looking into this.

Some cannabis products are also being marketed as pet food and health products for animals. The FDA has not approved cannabis for any use in animals and recommends pet owners talk with their veterinarians about appropriate treatment options for their pets.” via FDA, 2019.

Blood Pressure and CBD Oil

High doses of CBD oil may potentially drop blood pressure resulting in lightheadedness and possibly dizziness in people. It’s always best to consult with your veterinarian for the best advice prior to purchasing a CBD product. That said, the positive side of CBD oil use is that it may be good for patients with high blood pressure. CBD together with regular exercise and a healthy diet help to regulate hypertension.

A 2017 study by Dr. K Jadoon on CBD and its effects on blood pressure demonstrated the following:

The study concludes that “acute administration of CBD reduces resting BP and the BP increases stress in humans, associated with increased HR. These hemodynamic changes should be considered for people taking CBD. Further research is required to establish whether CBD has a role in the treatment of cardiovascular disorders.”

CBD Oil Interacts with Anti-Seizure Meds

A study researching CBD interactions with seizure meds in people added that “ Because all of the participants are also taking other seizure drugs while they are receiving the investigational therapy, investigators checked the blood levels of their other seizure drugs to see if they changed. “With any new potential seizure medication, it is important to know if drug interactions exist and if there are labs that should be monitored while taking a specific medication,” said lead author Tyler Gaston, MD,” via Science Daily.

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Dr. Gaston and her colleagues found that there were significant changes in levels of the drugs clobazam (and its active metabolite N-desmethylclobazam), topiramate, and rufinamide in both adults and children, and zonisamide and eslicarbazepine in adults only.

Except for clobazam/desmethylclobazam, however, the drug levels did not change outside of the normally accepted range. In addition, adult participants in the study taking clobazam reported sedation more frequently.

Additionally, when seizure patients were using valproate, they added that “Tests also showed that participants taking valproate and CBD had higher ALT and AST (liver function tests) compared with participants not taking valproate.

Very high ALT and AST indicate abnormal liver function, but significant ALT and AST elevation occurred only in a small number of participants (4 children and 1 adult), and the levels returned to normal after discontinuation of valproate and CBD.”

The study concludes that “The findings emphasize the importance of monitoring blood levels of antiepileptic drugs as well as liver function during treatment with CBD. “

A perception exists that since CBD is plant based, that it is natural and safe; and while this may be mostly true, our study shows that CBD, just like other antiepileptic drugs, has interactions with other seizure drugs that patients and providers need to be aware of,” said Dr. Gaston.”

Cytochrome P450

CBD as a natural supplement does not cause a “high” in pets, but may cause a reaction when used together with anti-seizure meds. Cannabinoids have been shown to inhibit cytochrome P450 enzymes by using up these enzymes, and by inhibiting how other enzymes work.

When cannabidiol oil is consumed by dogs in large amounts, a large group of enzymes may be altered in the same way that grapefruit alters enzymes.

Most pet meds are metabolized in the liver via certain enzymes that are made in it. CBD works in the same way that grapefruit does, and may use up all the enzymes and also alter the effectiveness of pet meds.

NSAIDs and Corticosteroids

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are a class of drugs commonly used to control pain and inflammation in dogs. NSAIDs help many dogs lead a life that is more comfortable for them, but what about interactions with CBD oil? CBD oil has the potential to make pet meds less effective.

That said, pet parents should take every precaution to ensure that there are no interactions with any of their pet meds or supplements, and even NSAID’s, corticosteroids, pet herbal supplements and vitamins. The potential for adverse reactions will also depend on the body chemistry of your pet and the dose of the prescription or supplement.

Administer CBD oil 2 hours before or 2 hours after giving pet meds or supplements.

NSAID’S include the following:

  • Rimadyl
  • Metacam,
  • Deramaxx,
  • Etogesic

Meds like Gabapentin when taken together with CBD can cause lethargy in pets. It’s important to discuss CBD use with your veterinarian prior to administering.

Common corticosteroids include the following:

  • Prednisone
  • Triamcinolone,
  • Dexamethasone,

The most common symptoms when using these are gastrointestinal issues like lack of appetite, vomiting, diarrhea, and even ulcers. We all know that pets cannot take both NSAID’s and corticosteroids at the same time, but what about cannabidiol oil and NSAID’s and corticosteroids?

CBD oil can also enhance the effectiveness of certain drugs and one may be able to lower the dose of pet meds or therapy when using CBD oil. Pet meds that are used for pain relief need to be administered carefully when using them together with CBD oil.