How long for cbd oil to stop working

How long does it take CBD oil to work?

In recent years, cannabidiol (CBD) oil has skyrocketed in popularity. Knowledge about how it works in the human body, however, has accelerated at a snail’s pace. If you’ve ever wondered, “How long does it take for CBD oil to work?” or “How long will the effects of CBD oil last?” you’re not alone.

In this article, we’ll answer these questions and cover how different consumption methods will alter your CBD experience.

How does CBD interact with the body?

CBD interacts with the brain and body through a number of mechanisms. Upon ingestion, CBD interacts with a wide range of proteins in the body and central nervous system. A key part of this interaction takes place within the endocannabinoid system (ECS) — specifically the CB1 and CB2 cannabinoid receptors.

When cannabidiol is introduced to the endocannabinoid system, it inhibits the absorption of anandamide, a natural cannabinoid molecule that regulates pain. Photo by: Gina Coleman/Weedmaps

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CBD also interacts with other receptor proteins not directly related to the ECS, such as the serotonin receptor 5-HT1A and vanilloid receptor TRPV1. Any potential anti-inflammatory and pain-relieving properties of CBD could stem from the activation of these additional biological pathways.

Bottom line: The relationship between CBD and the human body is complicated. The method of consumption, the quality of the CBD product, and individual body chemistry all determine how this cannabinoid moves through your body and how long it takes to leave your system.

The method of consumption matters

The method of consumption plays a critical role in how long it will take to feel the effects of CBD. CBD is available in many different forms, and each has an influence on the onset time, among other factors.

Ingestion

The most common method for CBD consumption involves administering a couple of drops directly into the mouth. Swallowing the oil will prevent the CBD from immediately entering your bloodstream, sending it instead through the digestive tract and eventually on to the liver, where it is broken down before finally reaching the bloodstream.

Studies show that when CBD compounds are metabolized by the liver, it undergoes what is called the “first pass effect,” where enzymes in the liver reduce CBD concentration before the remainder is finally sent to the bloodstream and circulated throughout the body.

When ingesting CBD edibles, the same principle applies. Let’s say, for example, you’re taking CBD gummies or adding a few drops of CBD oil into your favorite recipe. It will ultimately go through the same lengthy process and reduce the total CBD concentration in your bloodstream. With ingestion, it could be one to two hours before the effects of CBD finally set in.

Bottom line: Ingesting CBD via a tincture or a CBD oil-infused edible will result in a longer onset (up to two hours) and possibly weaker effects.

Sublingual

You can consume CBD oil sublingually by placing a few drops of CBD under your tongue and rubbing it into the tissue there with your tongue or finger for at least 30 seconds to a minute before swallowing. This will allow the mucous membranes in your mouth to absorb the CBD, partially bypassing the digestive system and liver, for much quicker entry into the bloodstream. Effects may be felt within seconds. Just like when you ingest THC edibles though, you’ll get a second onset of effects a couple of hours later when the CBD that wasn’t absorbed sublingually makes it through your digestive system.

Administering a couple of drops of CBD oil directly under the tongue is the quickest and easiest way to reap the potential benefits. Photo by: Gina Coleman/Weedmaps

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Bottom line: Expect to feel the effects of sublingual administration within 30 minutes. Any effects you feel should last an hour or more but be bolstered at about two hours.

Inhalation

Whether you’re smoking a high-CBD strain, puffing on a hemp flower pre-roll, or taking a draw from a CBD vape pen, inhalation is often seen as an effective method of delivery for CBD because of how quickly it’s absorbed in the body. When you smoke CBD flower or vape CBD oil, cannabinoids go directly to your lungs where they rapidly enter your bloodstream and circulate throughout your body. CBD reaches peak concentrations within three minutes after consumption, meaning the effects can be felt shortly after use.

Inhalation is often seen as an effective method of delivery for CBD because of how quickly it’s absorbed in the body. Photo by: Gina Coleman/Weedmaps

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Bottom line: Smoking CBD flower or vaping CBD oil is one of the fastest ways to experience the effects of CBD. Any effects you feel will set in almost immediately and last roughly an hour or slightly longer.

Transdermal

When it comes to easy, effective CBD dosing, transdermal patches have a lot going for them. Based on the same principles as nicotine or birth control patches, CBD patches deliver a long-lasting dose very efficiently. The cannabinoid readily diffuses into our skin, through our skin cells, and into the bloodstream, especially when it’s helped along by permeation enhancers. Patches can help with localized skin and muscle issues but they are right up there with smoking when it comes to getting as much of the CBD you consume into your bloodstream as possible. It’s also a discreet option that delivers a steady dose over hours.

CBD patches deliver a long-lasting dose very efficiently. Photo by: Shutterstock

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Bottom line: Using a transdermal CBD patch is an efficient, effective way to enjoy the cannabinoid’s effects, which set in within an hour and last for several hours, depending on the patch’s formulation.

Topical

When you apply topical CBD products directly to your skin, the CBD is absorbed and slowly interacts with localized cannabinoid receptors. In some cases, CBD-infused topicals should be applied liberally to overcome the low cannabinoid absorption rate of the skin. With topical application, any CBD effects you feel will peak after about 90 minutes. This method of administration is often used for chronic pain in specific areas.

Topical CBD is applied directly to and can be absorbed through the surface of the skin. Photo by: Gina Coleman/Weedmaps

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Bottom line: Applying CBD oil topically isn’t likely to have a profound effect, but it may help address mild discomfort in specific areas of your body.

Dosage matters

The way CBD interacts with and leaves your body depends on several factors that vary from person to person.

Bodyweight

Body fat influences the amount of CBD you need to feel an effect. The larger the body mass, the more CBD required to feel potential effects. Bodyweight and mass also affect how long CBD will remain in your system. Like THC, CBD is stored in fat cells and gradually eliminated from the body through urine and feces.

Metabolism

The metabolic rate of the individual also has some sway over how long CBD stays in the system. The body’s metabolism determines the time needed to break down and synthesize compounds, which affects how long it takes the body to process and metabolize the cannabinoid.

Your body’s metabolism affects how long it takes to process and metabolize cannabinoids. Photo by: Gina Coleman/Weedmaps

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Frequency of use

It’s not just your body that influences how long it takes CBD to work, but also the quality of the CBD product and how often it’s used. Once you acquire CBD oil, the next step is to find the optimal dosing regimen, including frequency of use. The answers will depend largely on the type of product, amount of CBD inside it, and the specific ailment you are targeting. Most reputable manufacturers will provide instructions on how to properly use the product, but experimentation may be required to find the optimal dose for you and your specific needs.

CBD dosage

Settling on the ideal CBD dosage is an important part of the treatment process, and will also impact how long CBD stays in your system. Hemp-derived CBD products are not intended to give the user a stoned buzz or intoxicated feeling, so there’s no need to be conservative with the dosage amount. Still, it’s recommended to start with a lower dosage and gradually increase it until the ideal effects are discovered.

If you’re brand new to CBD, start with a few puffs of a smokeable product, 1 milliliter of oil or tincture, or 10 milligrams of CBD if you’re consuming an edible product. Wait to see how you respond before consuming more.

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How long does it take CBD to get out of your system?

We’ve covered the factors that determine how long it takes for CBD to work, but what about how long it takes to get CBD out of your system? Again, it depends on many of the aforementioned factors that determine the effectiveness of the cannabinoid itself.

CBD can be detected up to 72 hours after smoking. Photo by: Gina Coleman/Weedmaps

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A 2018 review of existing CBD studies found that the estimated half-life of CBD was two to five days for those who took a daily oral dose. Other delivery methods delivered varied half-lives. Since you may feel the effects of CBD immediately after inhalation, this method is appealing for those seeking immediate, potential pain relief. The same study found that the half-life of smoked CBD was 31 hours.

How CBD affects drug test results

Some people may be apprehensive to try CBD over concerns that it could cause them to fail a drug test. It’s highly unlikely that CBD would show up on most drug screenings, as most tests specifically look for the presence of THC and THC metabolites. But even hemp-derived CBD can contain trace amounts of THC, so there’s technically a chance — albeit extremely slim — of receiving a false-positive test result from taking an unusually large dose of CBD oil (estimates range from 1,000 to 2,000 milligrams per day).

For those worried about THC showing up in their system, look for broad-spectrum oil or products that contain pure CBD isolate. Broad-spectrum oil, as opposed to full-spectrum oil, is refined to exclude the trace amounts of THC that may have been present in the hemp plant. Products with CBD isolate contain no THC or other plant-based cannabinoids. To find high-quality CBD, search for products that come with a certificate of analysis from a third-party testing lab to ensure that the information listed on the product label is accurate. Be careful not to confuse hemp seed oil or hemp oil, which seldom contain any CBD at all, with CBD oil. These products will provide a hearty dose of omega-3 fatty acids, but they won’t provide any potential pain-relieving or anti-anxiety effects.

Frequently asked questions

How long does it take for CBD oil to work orally?

Consuming CBD oil via sublingual administration will deliver any effects within 30 minutes. CBD edibles have the longest onset time, and it may take two hours to feel any effects.

How soon does CBD oil work for anxiety?

It depends on how you consume it. For the quickest potential anxiety relief, smoke high-CBD hemp flower, vape a CBD oil vape, or administer CBD sublingually, taking care to rub it in.

Does CBD oil actually do anything?

That depends on the person, the quality of the CBD oil, and the consumption method. If you’ve used a CBD product in the past and it did nothing, check whether it came from a licensed brand or retailer that performs third-party lab tests. If this is the case, the dosage might be at play. Unlike THC and most other cannabis products, CBD is non-intoxicating and you can experiment with large increases in your dose with little risk. If you take any prescription medication, be sure to check with your doctor or pharmacist before trying CBD in any form.

How long does it take for CBD oil to work for pain relief?

If you’re using a topical product for potential localized pain relief, it could take anywhere from a few minutes to an hour to feel a difference. Again, buy products from licensed brands and retailers that perform third-party lab tests to ensure you’re getting a legitimate product.

How Long Does CBD Oil Take to Work?

To understand how long CBD takes to work, you first need a basic understanding of what CBD is, and how different variables can impact its onset of action. In general, CBD is absorbed into the bloodstream within 20 minutes to 2 hours depending on the method of delivery. 1 Other variables like the dosage, full spectrum or THC-free, consistency, and quality can also play a role in how quickly you begin to feel the benefits of CBD. How long does CBD oil take to work? It really depends on your goals and expectations, along with other variables like your age, body weight, and metabolism.

However, for anyone trying CBD for a more serious issue, consistency and patience needs to be part of your wellness routine for the full potential of CBD to be realized.

  • 1) CBD Takes to Enter Your Bloodstream
  • a) Factor 1: Method of Intake
  • b) Factor 2: Dosage & Potency
  • c) Factor 3: CBD Quality
  • d) Factor 4: Individual Biology
  • e) Factor 5: Consistency
  • 2) Feeling Out How CBD Works for You
  • 3) What kind of CBD should I take?
  • 4) What time of day should I take CBD?
  • 5) How Often Should I Take CBD?
  • 6) How Long Does It Take for CBD to Work?
  • 7) After one month of CBD: how will I feel?

If you’d like to know more about what it takes to begin seeing results, read on as we explore the variables, but first watch my short video below!

How Long CBD Takes to Enter Your Bloodstream

As I mentioned above, the answer to how long CBD takes to work really depends on your own definition of the word “work.” Mild anxiety is going to be much quicker and easier to address than a more serious condition.

Simply put: the answer to this question isn’t a one-size-fits-all solution. It is a step by step approach that acknowledges how the benefits of CBD, and how long it takes to achieve them, may differ from different delivery methods and the issue at hand. For example: how long it takes CBD to work will differ drastically between sublingual oils, CBD capsules, and CBD topicals. So let’s get down to the nitty gritty!

Factor 1: Method of Intake

There are many different ways to consume CBD. Each of these methods has a different impact on how much, and how quickly, the CBD gets absorbed into your bloodstream. 2 This phenomenon is called bioavailability. It’s important to understand this because it will help you determine how much you’ll need to take to feel its effects; and you can also get an idea of how long it will take for your CBD to work.

CBD Bioavailability Chart

As you can see in the chart above, the consumption method of CBD is the biggest determining factor in how long it may take for CBD oil to work. The quickest and most bioavailable method of CBD consumption is through inhalation, but many states still prohibit the sale of CBD-rich hemp flowers for smoking. The next best is a sublingual oil or tincture, followed by ingestible CBD capsules and finally topicals.

Because CBD capsules have to travel through your digestive system, they have what’s known as a first-pass metabolism. This means that it’ll take longer to feel the effects of the CBD, or in medical terms – the bioavailability rate. (To clarify: this applies for all edible cannabis products, because all of them have to pass through your digestive system.)

On the other hand, CBD oil avoids first-pass metabolism by going straight through the capillaries under your tongue. This makes it the most effective method of delivery after smoking, and it means you’ll feel it quicker. 3 This is also the main reason we formulate our organic CBD oils with medium chain coconut oil. Because of its thin and viscous characteristics, it absorbs quickly when placed under the tongue.

There are other variables at play in how long it takes, but this should help you determine when your specific form of CBD will start working.

Factor 2: Dosage & Potency

The amount of CBD you’re taking every day will affect how quickly you will begin feeling its effects. In general, the more that you’re taking, the quicker you’ll feel it.

For example, if you take a high dose of CBD to Support a healthy Sleep Cycle, you’ll probably feel sleepy in about 15-30 minutes. In contrast, if you take a lower serving for general wellness or everyday aches or pains, it could take a few days of dosing to notice significant results. 4

How Much CBD Should I Take?

The bottom line is that when you’re choosing a CBD product, you should consider the type of results you’re trying to achieve and adjust your dosage accordingly. This may also include testing different consumption methods or a different application style. It can also depend on your body mass, and if you’re taking any prescription medications. 5

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Everyone is different, and this is something you need to dial in for yourself. A full dropper of our 750 mg CBD oil is 25 mg, which we think is a great daily serving to start with. But some people take more, and some need less. CBD can be a powerful supplement, especially when it contains THC alongside it. So it’s best to consult with your doctor to determine the right dose for you and avoid any CBD side effects.

Factor 3: CBD Quality

We’ve said it time and time again: not all CBD products are created equally. Because this market is largely unregulated, many brands on the market do very little to maintain the quality of their products. 6 Some CBD brands use ingredients that have impurities, additives, and adulterants which will significantly effect the safety of your product. This is why you should always look for a third party lab test to know that you’re getting a high quality CBD product, along with the USDA organic seal.

We also recommend looking for a full spectrum CBD product, which contains more cannabinoids than just CBD. Just like CBD, these other cannabinoids don’t get you high; but they do have a synergetic effect that heightens your body’s response through the “entourage effect.” 7 One of those cannabinoids is probably one you’ve heard a lot about, and that’s THC. In order for a product to truly be considered full spectrum, make sure it contains trace amounts of THC. The legal amount is no more than 0.3 percent of total dry weight.

The origin of the raw hemp plant material is another key factor that determines the quality of your product. Hemp is a powerful bioaccumulator, meaning that it soaks up all the nutrients and toxins in the soil it grows in. If the soil isn’t pre-tested for toxins, pesticides, or heavy metals, those things could end up in your CBD. That’s why you should only use CBD products made from hemp grown in the USA, and preferably in Kentucky. In addition, if the farmer uses synthetic fertilizers, or if the field doesn’t go through a multi-year crop rotation, there will be fewer nutrients in the soil and the hemp will contain less CBD. 8

You can avoid all of these problems by opting for an organic cannabis product that’s been certified organic by the USDA. As we explore in this article, the USDA has strict guidelines for organic farming and processing. This means that USDA certified organic products will be responsibly sourced and of higher quality. 9

Factor 4: Individual Biology

Although you can count on certain effects to take place, no two people respond exactly the same to CBD, even if they have the same consumption, the same delivery method, and the same body composition. One person could feel their CBD tinctures in 10 minutes, yet someone else could take the same dose and feel it in an hour. 10

There are several key considerations that fall into this category, and they all affect the amount of time it will take to feel CBD’s effects.

Body Weight

Like most cannabinoids, CBD is fat-soluble. Those who weigh more tend to have more fat cells in their body, which means that they’ll absorb and store CBD for longer in their body.

While this isn’t necessarily a bad thing, it does mean that people with more fat cells in their body will most likely need more time to adjust. It’s not all bad news, though: the higher your body mass, the longer it takes for CBD to work. 11

Metabolism

While individual metabolism does involve burning calories, it also affects how your body breaks down compounds like CBD. Depending on your age, your lifestyle, your digestive system, and your genetic profile, your metabolism can function at different rates. This is what we call our metabolic rate – and we all have different ones! 12

If you exercise regularly and have a high metabolism, you’ll feel the effects come on faster; but you’ll also feel it wear off more quickly. On the other hand, if you have a slow metabolism, you’ll notice that it takes longer to feel your CBD coming on; and it will stay in your body for longer.

Endocannabinoid Balance

CBD is part of a unique set of compounds called cannabinoids. These compounds interact with a biological system found in nearly all animals. It’s called the endocannabinoid system (ECS), and its cannabinoid receptors are found throughout your entire body. While we’re just beginning to understand how the ECS works, research suggests that it’s responsible for many of your biological functions like your mood, sleep, appetite, and pain response. 13

If your ECS is imbalanced, you could experience a large range of negative symptoms as a result. While the science is still out on this subject, CBD could help to alleviate these symptoms by attaching to the receptors and rebalancing your system. In general, the more your endocannabinoid system is imbalanced, the longer it will take to feel the effects.

While there’s no way to quantify how much of an imbalance you’re experiencing; you can probably gauge this yourself by assessing the severity of your symptoms.

Factor 5: Consistency

For some people, the positive effects come immediately. A lot of people will notice that they’re experiencing less stress, less tension, and better sleep after just one dose of CBD — but this is just from anecdotal reports. For others, it might take a few weeks to notice the powerful effects of CBD. So if you don’t feel it right away, be patient.

Some impatient people might give up after a few CBD doses and brush it off as snake oil that doesn’t work. While these people might be taking a bad-quality product, they’re also ignoring one of the key properties of CBD oil — take it consistently.

Regardless of what you’re feeling, the positive results come slowly. The key to getting the most benefits out of your CBD is consistency! A consistent, daily dose will eventually restore balance your ECS; and you’ll be glad you stuck with it.

Feeling Out How CBD Works for You

When you’re new to CBD, the first thing to know is that the effects take a few days to become noticeable. That means when you begin taking CBD every day, it’s good to be mindful of how your body responds to your daily CBD dosage. To discover its full effects, we recommend trying it for a full 30 days.

Your first 30 days on CBD is an important time to better understand your body and how it responds. Below we answer many of the most common beginners’ questions about CBD.

The potential therapeutic benefits that CBD oils and tinctures offer are becoming more recognized, making people more interested in getting started. The first 30 days can be a trial and error time in finding what works best for you, the individual. After reading these answers to the most common questions, you are likely to add a cannabis supplement into your everyday routine soon.

What Kind of CBD Should I Take?

For first time users, we always recommend starting with full spectrum CBD oil, which you take sublingually — which means a dropper of oil under your tongue for 30 to 60 seconds to let it absorb through the mucous membrane in your mouth.

Some people have trouble taking our CBD hemp oil under the tongue, and so they prefer the CBD capsules. They are also worth considering if you’re experiencing inflammation in the lower digestive tract, as capsules get further down into the gut.

People looking for pain relief in a specific area often apply a CBD lotion on the affected area, while avoiding the eyes and mucous membranes. For best results, we recommend pairing CBD lotion with sublingual oil, and using the same delivery methods at the same time everyday.

You’ll also always want to make sure whatever CBD product you are using has third party lab tests. The best companies have a QR code, and all of their company information, and testing lab information readily available to be reviewed before or after purchase. In order for CBD oil to work, you must first make sure that what you’re taking is real! If you can’t view the third party test results before making your purchase, then hold off until you can do more research.

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Unfortunately, many unscrupulous brands sell fake CBD oil. 14 This is actually just hemp seed oil with a fake concentration listed on the bottle. You’ll also want to stay away from any brand that is making lofty health claims about its CBD oil. No medical claims regarding full spectrum CBD oil have been approved by the FDA, as of 2021. 15

What Time of Day Should I Take It?

This answer is different for everyone. The important thing is to find a time of day to best incorporate CBD into your daily routine. If you’re suffering from discomfort and inflammation during the day, maybe it’s best to take it in the morning. But if you’re using CBD because you’ve read reports that it can help you sleep, then taking it just before bedtime is your sweet spot.

How Often Should I Take CBD?

To begin, start taking CBD once per day, a full dropper of 25 milligrams, or 50 milligrams if you’re using our extra-strength CBD oils. See how you’re feeling and sleeping. For first time users, it can be good to “load dose” at first — taking larger than normal servings. That means, take a full dropper in the morning, and another full dropper before bedtime.

You will know if you have taken too much if you feel groggy in the morning, or if you experience diarrhea symptoms. 16 If you feel these side effects, dial back your current daily dosage to find something that works best for you.

How often you take CBD may also play a role in a drug test or work-related drug screenings. After taking CBD oil consistently for a period of weeks, the cannabinoids begin to build up within our systems, especially in fat cells, which could cause you to test positive during drug screenings. 17 If drug testing is a concern for your job, talk to your HR department before you start taking CBD consistently. You may also consider switching to a CBD topical, which has a far lower risk of showing up on a drug test.

How Long Does It Take For CBD Oil To Work?

It takes a few days for CBD to work, and it’s not something that you’ll notice right away. Be mindful of any pain, anxiety, and changes in sleep patterns as you work through your first week. Keep journal entries to track sleep and progress, and the amount of CBD you’re taking. This will help you be aware of the effects of CBD on your body. Understand that health benefits from natural supplements like CBD edibles, CBD tincture and oils don’t happen overnight. It takes time for the human body to adjust after implementing several different changes into our lifestyle. It also depends on the amount of CBD you’re taking to really experience the true effects of hemp derived CBD products .

After One Month of CBD: How Will I Feel?

After a month of CBD usage, you’ll likely feel different. 18 But if you don’t believe us, try taking it for one month consistently, and then don’t take it for a week. Those bad feelings may return. That’s when you’ll know how CBD makes you feel, and you’ll be ready to order your CBD oil here. At Cornbread Hemp, we are passionate about producing our Flower-Only™ full spectrum, USDA organic hemp extract for consuming CBD in several different effective methods. And because our third-party lab partner tests every batch, you’ll never need to worry about potentially negative side effects from any harmful contaminants.

About the Author

Dr. Leslie Mudd, PharmD

A board certified oncology pharmacist with 25 years experience at the James Graham Brown Cancer Center in Louisville, Kentucky, Dr. Leslie Mudd now serves as the Cornbread Hemp resident pharmacist and medical expert. Read Dr. Mudd’s full author bio here.

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11) Millar SA, Stone NL, Yates AS, O’Sullivan SE. A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans. Front Pharmacol. 2018;9:1365. Published 2018 Nov 26. doi:10.3389/fphar.2018.01365. Throughout article

12) Urasaki Y, Beaumont C, Workman M, Talbot JN, Hill DK, Le TT. Potency Assessment of CBD Oils by Their Effects on Cell Signaling Pathways. Nutrients. 2020;12(2):357. Published 2020 Jan 30. doi:10.3390/nu12020357. Throughout article

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14) VanDolah HJ, Bauer BA, Mauck KF. Clinicians’ Guide to Cannabidiol and Hemp Oils. Mayo Clin Proc. 2019;94(9):1840-1851. doi:10.1016/j.mayocp.2019.01.003. Under the “Finding a Quality Product”

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All rights reserved. The statements made regarding these products have not been evaluated by the Food and Drug Administration. The health effects and benefits of CBD products have not been confirmed by FDA-approved research. Hemp derived CBD products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to health information from licensed health care practitioners. Please consult your health care professional about potential interactions with prescription medication, or about other side effects before using any product. Taking too much CBD, and high doses of CBD may also cause undesired side effects. You should always consult with your doctor or another health care provider if you are considering making any changes to your lifestyle, diet or nutrition. Any CBD product is not intended for those who are pregnant or breastfeeding, please consult your doctor for more information before choosing to use CBD.

Cornbread Hemp works with cannabis plant suppliers who guarantee an equal to or less than 0.3 percent THC content. While there are no psychoactive side effects with these trace amounts of no more than 0.3% THC, it is possible that users may fail a drug test. Cornbread Hemp does not take any responsibility in the instance a customer fails a drug test while using any form of CBD products. Check state laws before travelling with any hemp derived CBD products.