How many mg of cbd oil for parkinson’s

CBD Oil for Parkinson’s Disease: Can Hemp Oil Help Parkinson’s Patients?

CBD can be a healthy, natural alternative to traditional treatments for Parkinson’s Disease.

Studies show that CBD, or cannabidiol, also referred to as CBD-rich cannabis, may help with managing debilitating symptoms of this condition, including the non-motor ones.

It’s actually possible to live a productive and happy life despite being diagnosed with Parkinson’s. When you take CBD oil, you won’t experience the adverse side effects of prescription medications; you also won’t get the high effect associated with using marijuana. And while traditional treatments may become less effective over time, CBD users are reporting long-lasting benefits.

Of course, we’re not saying CBD is a miracle drug — it’s not even a drug in the first place — but a high-quality CBD oil can improve your daily life as a Parkinson’s patient.

CBD is gaining momentum as a versatile supplement for a wide range of other conditions, including anxiety, epilepsy, pain, sleeping difficulty, or neurodegenerative disorders.

Everybody wants to capitalize on the booming market now, so how do you choose the right product from so many different brands?

This article will help you understand the potential benefits of using CBD oil for Parkinson’s Disease on top of highlighting the best companies whose products actually work.

Parkinson’s Disease Symptoms

Parkinson’s disease (PD) is a neurological condition that impacts a person’s nervous system, usually appearing at the age of 60. In simple words, brain cells that release the neurotransmitter dopamine — which sends messages to the body about the movement — become damaged and start to degenerate.

This causes a variety of motor issues, including but not limited to tremors, lack of facial expression, problems with balance, and stiffness in joints and muscles.

Moreover, Parkinson’s Disease may also lead to the development of Parkinson’s disease dementia (PDD), which compromises one’s cognitive performance, such as the ability to remember things, pay attention, or make decisions.

Some people confuse PDD with Lewy Bodies Dementia (DLB). However, with DLB, cognitive problems appear prior to motor issues. Both diseases are progressive, meaning the symptoms will deteriorate over time, and unfortunately, there’s no treatment that could cure people out of PD.

Initial symptoms of Parkinson’s Disease are mild and may include:

  • Lack of facial expression
  • Balance issues
  • Difficulty sitting or standing
  • Slowness of movement (Bradykinesia)

People with Parkinson’s Disease struggle with walking as the disease progresses. There’s even a phenomenon called Parkinsonian gait, which refers to a stooped posture, shuffling of the feet, and limited arm movement.

Other health problems in people with PD include:

  • Slurred speech
  • Memory loss
  • Difficulty maintaining focus
  • Impaired judgment
  • Visual hallucinations
  • Delusions
  • Loss of smell
  • Trouble swallowing
  • Constipation

People with Parkinson’s Disease may also suffer from anxiety, apathy, irritability, depression, pain, and insomnia. As mentioned, many PD patients develop Parkinson’s dementia over time.

Prescription medications to alleviate the symptoms of the disease may be effective, but they tend to lose efficacy over time, requiring larger doses to provide relief — which often leads to adverse side effects such as drowsiness, blurred vision, lightheadedness, nausea, vomiting, diarrhea, dry mouth, heartburn, loss of appetite, and more.

Not to mention the risk of lethal overdose.

It’s no wonder that people with Parkinson’s disease often seek alternative forms of treatment.

Let’s see how CBD could be used for Parkinson’s disease.

How Could CBD Oil Help with Parkinson’s?

While doctors haven’t been using CBD oil for Parkinson’s disease long-term, and research into the benefits of CBD for this condition only began a few decades ago, current findings are very exciting. Studies suggest that CBD may have some positive effects on certain symptoms of Parkinson’s disease, especially when it comes to anxiety, depression, and sleep difficulties.

Tremors

Common treatments for Parkinson’s Disease can result in medicine-triggered tremors or uncontrolled muscle movements. Continuous use of such medicine could make this symptom even worse. One older and smaller study suggested that CBD may be a possible solution due to its ability to help ease these muscle movements [1].

A recently published study[2] conducted by Brazilian researchers showed that CBD lowered tremors and anxiety that occurred during a public speaking test for people over 60 with Parkinson’s disease. Participants who took 300 mg of CBD before giving a speech, which is a classic anxiety-inducer, experienced milder symptoms than a control group who took a placebo.

Another study from researchers Alyssa S. Laun and Zhao-Hui Song from the University of Louisville, Kentucky, made a significant discovery a few years ago when they found that CBD is an inverse agonist of the CPR6 receptor found primarily in the basal ganglia area of the brain, which connects to the brainstem and cerebral cortex [3]. This receptor is responsible for many important functions in our bodies, such as movement, emotion processing, and learning. This means that CBD has a strong affinity to this receptor, providing beneficial effects against the symptoms of cerebral palsy and Parkinson’s. Any rise in dopamine levels would counteract the slow decrease of dopaminergic neurons experienced by PD patients.

Pain

A small study of 22 people with Parkinson’s found that taking cannabis helped improve pain [4]. However, this study involved medical marijuana, which contains both CBD and THC in various ratios.

However, animal studies have suggested that CBD alone may be effective in reducing pain and inflammation, two symptoms that affect people with PD frequently [5].

Psychosis

Psychosis is a sort of collateral damage caused by Parkinson’s disease. It can lead to hallucinations, delusions, and delirium. It is more likely to occur during the later stages of the disease and affects up to 50 percent of people with PD [6].

While antipsychotic medications are available to treat this symptom, some people have wondered if CBD might help too.

According to a 2009 study, the severity of psychosis and its symptoms were reduced in individuals with Parkinson’s disease [7]. More interestingly, CBD also didn’t cause any side effects.

Sleep

A lack of quality sleep caused by sleep disruption is a serious problem for people with Parkinson’s disease. Vivid dreams or nightmares, as well as an abrupt movement during sleep, can heavily impact your sleep cycles. Studies have found that both cannabis and CBD alone might help with sleep deprivation [8].

Overall Quality of Life

Researchers have suggested that the many potential benefits of CBD can translate to improved quality of one’s life. This is a major concern for people diagnosed with Parkinson’s Disease, as the condition affects various both physical and mental health.

One study found that people with Parkinson’s disease and no psychiatric symptoms or conditions experienced an improved quality of life while taking CBD [9]. However, this study was conducted in a very small group of people, so further research is needed to draw further conclusions on these findings.

What Does the FDA Say About Using CBD Oil for Parkinson’s?

CBD oil hasn’t been approved by the FDA as a treatment for Parkinson’s disease. In fact, there are no FDA-approved cannabis treatments for this condition as of today. However, the FDA did acknowledge a CBD-based medication, Epidiolex, to treat two types of drug-resistant epilepsy.

Researchers from the University of Colorado are using Epidiolex to analyze its benefits on people with Parkinson’s-triggered tremors. The study is currently in its second stage.

Can You Use CBD Oil as a Prevention for Parkinson’s?

Studies have suggested that CBD may be able to help prevent Parkinson’s disease, but the current data comes only from animal models.

The research also suggests that CBD can do nothing to help treat PD after its onset. Based on this, it may only be useful as a preventive supplement.

However, most clinical trials only use CBD after a person is diagnosed with Parkinson’s disease. This is important because about 60 percent of the dopamine-receptive neurons in the brain are already destroyed by the time a person begins showing the symptoms of their condition.

It’s also difficult to predict who will develop Parkinson’s and who will be more resistant to this disease. There are only a few preventive strategies, and thus far, we don’t know if CBD can help everyone.

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How to Administer CBD for Parkinson’s Disease?

If you’re about to use CBD for the first time, you may be wondering how to take it the right way to maximize the benefits for Parkinson’s disease.

You can buy CBD in various forms, including:

  • CBD oil (sublingual drops). CBD can be swallowed or absorbed sublingually (beneath the tongue). This is a good option if you don’t like to take capsules and want to precisely measure out your dose. The calming effects of CBD usually take hold around 15-30 minutes after ingestion and may last for up to 6 hours.
  • Capsules. This form of CBD is a good option if you’re looking for a premeasured dose of CBD in your supplement. You just take as many capsules as recommended by your physician. The downside of taking CBD capsules is their delayed onset and lower bioavailability since they have to pass through the digestive system before reaching the bloodstream.
  • Edibles.CBD-infused is becoming more popular these days. Gummies are by far the most common option. They work in a similar manner to capsules. They usually kick in after 40–120 minutes and last for up to 10 hours. Edibles are a discreet way to deliver a dose of CBD.
  • Topicals. Products like lotions and creams may be effective for localized problems because they deliver the CBD to the cannabinoid receptors located in the deeper layer of the skin. From there, CBD can produce its soothing effects on the body, reducing inflammation, stiffness, and pain.
  • Vape pens. CBD oils can be mixed with thinners such as vegetable glycerin to be vaporized and inhaled. The effects take hold quickly if you use this route of administration and can deliver more CBD to your system than any of the above methods. However, vaporized CBD will last shorter than it does when you take CBD oil or edibles, usually up to 2-4 hours.

Possible Side Effects of CBD Oil

Most studies have concluded that CBD is a safe and well-tolerated substance. The WHO issued a complete report on the safety and efficacy of cannabidiol, supporting the earlier findings. CBD rarely causes any side effects, and if they do happen, they tend to be mild.

The side effects of CBD oil include:

  • Dry mouth
  • Changes in appetite
  • Sleepiness
  • Fatigue
  • Diarrhea

CBD can also interact with prescription and non-prescription medications, so make sure to always consult your doctor before taking CBD, especially if you’re on medications that are metabolized by the Cytochrome P450 system. If your doctor tells you not to eat grapefruit along with your meds, the same rule applies to CBD because they use an identical mechanism, blocking the p450 system from metabolizing the active ingredients in those medications.

Best CBD Oil for Parkinson’s Disease: Our Top Picks in 2022

1. Royal CBD (Best CBD Oil for Parkinson’s Disease)

Get 15% off all Royal CBD products. Use code “CFAH” at checkout.

Product Details

Potency 250 mg – 2500 mg
Available Flavors Natural, Berry, Mint, Vanilla
CBD per serving 8.3 mg – 83.3 mg

Why Royal CBD Oil is the Best CBD Oil for Parkinson’s Disease

Royal CBD is a premium brand from Nevada that sells full-spectrum CBD oil from organic hemp. The company was started by a group of cannabis activists to leverage the quality standards for making CBD products in the industry. On top of its best-selling CBD oil, Royal CBD also offers full-spectrum softgels, THC-free gummies, and two types of broad-spectrum topicals.

Royal CBD oil comes in four strengths. Users can choose between 250 mg, 500 mg, 100 mg, and 2500 mg of total CBD. If you have problems holding the natural CBD oil in your mouth, you can pick one of the four flavored options. The 2500 mg is only available in the unflavored variant because adding flavorings would compromise its cannabinoid profile and the efficacy of the entourage effect from other cannabinoids.

The oil contains the full-spectrum of phytochemicals, including CBD, trace cannabinoids, terpenes, and flavonoids that boost the efficacy of cannabidiol. To further enhance the bioavailability of this hemp extract, the guys at Royal CBD have suspended it in food-grade MCT oil from coconut. The addition of MCT oil also brings other benefits to the table, including a stable source of energy for the brain and the presence of heart-healthy essential fatty acids.

I found the 2500 mg potency particularly helpful for non-motor problems like anxiety, irritation, and fatigue. This CBD is also decent at easing pain and inflammation, not to mention that it can last for up to a few months if you benefit from lower doses in your routine.

The entire Royal CBD collection is made from US-grown organic hemp, extracted with supercritical CO2, and rigorously tested in a certified laboratory for potency and purity.

  • Made from locally grown organic hemp
  • Extracted with supercritical CO2
  • Infused with full-spectrum CBD
  • Available in 4 strengths and flavors
  • Up to 2500 mg of CBD per bottle
  • 3rd-party tested for potency and purity
  • Great natural flavor
  • Not available in local CBD stores (this may soon change)

2. Gold Bee (Best Organic Formula)

Product Details

Potency 300 – 1200 mg
Available Flavors Natural, Honey
CBD per serving 8.3 mg – 33.3 mg

About Gold Bee

The “runner up” title in our ranking of the best CBD oils for Parkinson’s Disease belongs to Gold Bee, which is another premium manufacturer from Nevada. This company makes unique CBD oils that are infused with a natural honey flavor, hence the Bee name. The guys at Gold Bee have partnered with their local growers from Colorado to create their own blend of high-CBD strains.

Gold Bee CBD oil comes in four different concentrations, from 300 mg to 1200 mg CBD per bottle. And just like Royal CBD, this brand also uses full-spectrum CBD in its product, so you’re getting the whole hemp goodness from the original plant. When it comes to symptoms like anxiety and problems with focus, I’ve noticed similar results to Royal CBD oil, but I think Gold Bee products are less affordable in the long-run.

Still, these are the best CBD oils for Parkinson’s disease in the mid-potency range.

  • Sourced from US-grown organic hemp
  • Contains full-spectrum CBD
  • Up to 33 mg CBD/mL
  • Great potency range for beginners
  • Third-party tested for potency and purity
  • Great honey flavor
  • No high-strength CBD oils

3. CBDPure (Top Transparency)

Product Details

Potency 100 – 1000 mg
Available Flavors None
CBD per serving 3.3 – 33 mg/mL

About CBDPure

I highly recommend CBDPure for those who are just starting out with CBD. The strengths of the oils offered by this company are great for beginners. The lowest strength contains 100 mg of CBD, which is perfect if you want to see how taking CBD affects your body. It delivers 3.3 per half a dropper of the oil, so it should be good for managing mild symptoms.

For moderate problems, you can use the higher potencies. These include 300 mg, 600 mg, and 1000 mg of CBD per bottle. The last potency is a standard option for users who already have some experience and their daily dose doesn’t exceed 30 mg.

This brand is a textbook example of transparency. You can easily access the lab reports of their CBD oils and softgels through the company’s website.

  • Sourced from organic Colorado-grown hemp
  • Extracted with supercritical CO2
  • Lab-tested for potency and purity
  • 90-day return policy
  • Only two forms of CBD available
  • Low potency
  • Premium pricing

4. Hemp Bombs (Best CBD Isolate)

Product Details

Potency 125 – 4000 mg
Available Flavors Natural, Acai Berry, Orange Creamsicle, Peppermint, Watermelon
CBD per serving 4 – 133 mg/mL

About Hemp Bombs

If you’re looking for a company that offers CBD oil made with a broad-spectrum of cannabinoids or based on CBD isolate, Hemp Bombs is by far the best manufacturer on the market. The company specializes in making pure CBD oils in a wide range of potencies, with up to 4000 mg of CBD per bottle.

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This CBD oil is a good alternative for people with Parkinson’s disease who don’t want to include any THC into their regime for some reason. Broad-spectrum or isolated CBD can work for you if you’re tested for THC at work, as large doses of full-spectrum CBD oil taken regularly can result in a false-positive result on the screening.

However, those using CBD oils with zero THC should be aware that the synergy from other cannabinoids and terpenes will be either incomplete, or there will be no synergy at all (if using isolate).

  • Sourced from organic hemp
  • Extracted with CO2
  • 0% THC
  • Available as broad-spectrum or isolate
  • Third-party tested for CBD and contaminants
  • Up to 4000 mg of CBD per bottle
  • 5 strengths to choose from
  • Infused with synthetic flavorings
  • No “entourage effect” from other cannabinoids and terpenes
  • Most people don’t need such high doses of CBD oil in their routine

5. CBDistillery (Best Price)

Product Details

Potency 250 – 5000 mg
Available Flavors None
Potency 8.3 – 166 mg/mL

About CBDistillery

As one of the industry’s trailblazers, CBDistillery definitely deserves a mention on our list of the best CBD oils for Parkinson’s disease considering how the company has managed to maintain its stellar reputation throughout the years. Not only did CBDistillery not rested on the laurels, but it also became one of the biggest suppliers in North America.

CBDistillery’s mission is to provide high-quality CBD oils affordable for everyone. The company sells hemp extracts in full-spectrum and broad-spectrum variants. The latter is referred to as “pure oil” and contains all the non-psychoactive cannabinoids and terpenes from hemp, but without any THC in the final product.

This company covers the entire potency range for CBD oils, from 250 mg to a whopping 5000 mg of CBD per bottle. At 166 mg of CBD in each mL, the strongest version is enough to get yourself stocked with CBD for months to come.

The only downside of CBDistillery’s products is that they’re not made with organic hemp. Nevertheless, it’s still one of the best companies in this price range, so if you’re shopping for CBD on a budget, this is a rock-solid supplier.

Comparing CBD with Levodopa for Parkinson’s

Levodopa is an established treatment for Parkinson’s disease. Although it’s not perfect, it’s currently the most effective treatment for PD. It helps boost the level of dopamine in the brain.

Levodopa is effective at targeting the motor symptoms of the condition, such as tremors or muscle stiffness.

However, this medicine does little to combat the nonmotor symptoms of Parkinson’s disease. These are the problems that can significantly affect a person’s daily life. They include anxiety, sleep disturbance, fatigue, irritation, and depression.

Furthermore, prolonged use of levodopa may result in side effects like elevated anxiety, agitation, confusion, and nausea. It may also trigger tremors that result from the medication itself, not PD.

CBD appears to help with those nonmotor symptoms and potential side effects, rather than physical problems. A study with more than 200 participants found that regular use of cannabis was highly effective on non-motor symptoms of Parkinson’s Disease. However, this study included a combination of THC with CBD, not CBD oil alone.

Final Thoughts on Using CBD Oil for Parkinson’s

There is no cure for Parkinson’s disease. Once diagnosed, patients can only slow their progression.

However, there are ways to manage its pesky symptoms. One of them is using CBD oil. If you’re planning to try it out, remember to make an appointment with your doctor first. This is to make sure that you don’t experience any side effects of potential drug interactions. In addition, your doctor can also give you professional advice on finding the right dose.

Although more research is needed to confirm the benefits of CBD oil for Parkinson’s disease, the best product that may support official treatment is Royal CBD oil. Made from organic hemp and using supercritical CO2, this product is pure, safe, and available in a wide range of potencies to suit different CBD needs.

Do you know anyone who takes CBD oil to cope with the symptoms of Parkinson’s disease? Does it help? Let us know in the comment section below!

Nina Julia

Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

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CBD for Parkinson’s Disease

Parkinson’s disease is a neurodegenerative disorder that progressively causes neurons to die. One function of neurons is to create a neurotransmitter called dopamine, a chemical messenger responsible for sending messages between neural cells in the brain. Parkinson’s disease primarily affects dopamine-producing neurons in an area of the brain called the substantia nigra, causing critically low levels of dopamine that negatively affect motor function.

The result of this is a gradual loss of motor control, with symptoms starting gradually, usually with a noticeable tremor in just one hand. However, people with Parkinson’s disease also often exhibit emotional and behavioral changes, including sleeping problems and depression. Taken together, this makes Parkinson’s a debilitating disease that affects the patient, but also those around them.

The cause of Parkinson’s disease is still unknown and there is no cure for it.

Symptoms of Parkinson’s Disease

People with Parkinson’s typically start experiencing symptoms in the later stages of the disease, after a significant number of neurons have been damaged or lost. Symptoms develop slowly over multiple years, and they differ from person to person. Because symptoms often differ from one person to the next, not all symptoms listed below are necessary for a Parkinson’s diagnosis. Younger people in particular may only exhibit one or two of these symptoms, especially in the earlier stages of the disease.

While a variety of other symptoms may occur, the primary motor symptoms of Parkinson’s disease include:

Tremors that tend to occur at rest, is usually slow and rhythmic, occurring first in the hand, foot, leg, jaw, chin, mouth, or tongue—and eventually spreading across the body

A sensation of internal tremors, which are not necessarily visible to others.

Rigidity including tightness or stiffness of the limbs or torso

Bradykinesia, or “slow movement,” a reduced or mask-like expression of the face, blinking less frequently

Difficulties with fine motor coordination

Postural instability including an inability to maintain a steady, upright posture, or to prevent a fall, that becomes more pronounced in the later stages of the disease, this symptom causes

Walking or gait difficulties that may begin as a small change in the way the arm swings while walking and evolving into a slow, small, shuffling gait, rapid small steps, or freezing episodes in which the feet appear to be glued to the floor

While they are less noticeable—and often overlooked because of the disease being a movement disorder—there are also many associated non-motor symptoms of Parkinson’s. Disturbances in the sense of smell, eye and vision issues, sleep problems, depression, anxiety, pain, psychosis, fatigue, cognitive changes, weight loss, lightheadedness, sweating, melanoma, personality changes, and gastrointestinal, urinary, and sexual issues can all occur in patients of Parkinson’s disease.

Parkinson’s Disease Medications & Treatment

There is no cure for Parkinson’s disease. Because symptoms don’t exhibit themselves until the later stages of the disease, early diagnosis is difficult—but scientists continue to search for ways to identify the early onset of Parkinson’s. While no treatment options currently available can slow or halt the progress of Parkinson’s disease, there are treatments available to improve its symptoms.

Pharmaceutical Interventions
Almost all Parkinson’s patients will eventually require medication to treat their motor symptoms. Several classes of medications are available, and often patients will be prescribed various strengths, formulations, and combinations of medications to improve their symptoms. These include:

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Levodopa works by being converted to dopamine in the brain. Side-effects include nausea, usually requiring it to be taken with carbidopa. If symptoms return between doses (OFF periods) an infison of levodopa that is administered through a tube called duopa, a powder form of levodopa which can be inhaled, or the new medication istradefylline (Nourianz) may be prescribed. Levodopa treatments are often delayed as long as possible as its effects wear off over time and it eventually stops working, causing the patient to develop movement problems called “motor fluctuations”.

Safinamide (Xadago) is prescribed when patients taking levodopa and carbidopa have a breakthrough of Parkinson’s symptoms that were previously under control. Side effects include trouble falling or staying asleep, nausea, falls, and uncontrolled, involuntary movements.

Dopamine agonists that imitate the action of dopamine in the brain to treat the motor symptoms of Parkinson’s disease. Examples include pramipexole, rot ropinirole and igotine that can be taken on their own or with levodopa. Side effects can include nausea, orthostatichypotension, hallucinations, somnolence, and impulse control disorders.

Non-Pharmaceutical Interventions
The most common non-pharmaceutical interventions include lifestyle changes that can help slow disease progression and make symptoms more manageable. These include eating a healthy diet and a proper exercise program to help maximize the potential of medications, increase energy, and promote general health and well-being in Parkinson’s patients.

Physical, occupational and speech therapies can help with walking and gait issues, fine motor skills, and speech and language issues that may arise with Parkinson’s disease while deep brain stimulation (DBS) may improve symptoms in certain patients.

CBD for Parkinson’s Disease

Research & Scientific Evidence

A handful of studies have investigated the effects of cannabidiol (CBD) to treat Parkinson’s disease and symptom management. However, the main body of evidence showing that CBD has promise as an effective treatment for this disease lies in studies relating to adjunct actions and complications from the disease including oxidative stress, neural inflammation and neurodegeneration.

One such study is from 2011 in which researchers published the findings of the journal Psychopharmacology. Because of many neurodegenerative disorders involving cognitive deficits, they assessed whether the anti-inflammatory, and neuroprotective effects of CBD could be useful in the treatment of memory impairment associated to these diseases.

Using an animal model of cognitive impairment induced by iron overload, they tested the effects of CBD in memory-impaired rats in both a single dose as well as continued use. In the first experimental condition, the researchers administering a single dose of either 5.0 mg/kg or 10.0 mg/kg of CBD immediately after a training session of the novel object recognition task. They continued a daily intraperitoneal CBD injection for 14 days to examine chronic use and performed object recognition training 24 hours after the last dose and a retention tests 24 hours after training.

They found that a single dose of 10.0 mg/kg of CBD recovered memory while repeated CBD administration of either CBD dose improved recognition memory. They concluded that the evidence suggests that CBD shows potential for the treatment of cognitive decline associated with neurodegenerative disorders.

21 Parkinson’s disease patients without dementia or comorbid psychiatric conditions were assigned to three groups of seven subjects each. The control group was treated with a placebo, the first experimental group with 75 mg/day of CBD and the second experimental group with 300 mg/day of CBD. Participants were assessed in respect to motor and general symptoms, well-being and quality of life, and possible neuroprotective effects one week before and again, during the last week of treatment.

Although they didn’t find a statistically significant different between the group for motor and general symptom outcomes or neuroprotective effects, they did find that the patients treated with 300 mg/day of CBD had a significant improvement in their quality of life. However, the researchers also noted that studies with larger samples and specific objectives are required before definitive conclusions can be drawn.

Bonus:
In contrast, the latest research from 2020 suggests that CBD can help with motor symptoms, specifically tremors. In the Journal of Psychopharmacology, researchers published the results from their study aimed at evaluating the impact of a single dose of 300 mg CBD on anxiety measures and tremors induced by a Simulated Public Speaking Test (SPST) in individuals with Parkinson’s disease. They found that a single dose of 300 mg CBD not only decreased anxiety in patients with Parkinson’s disease but that there was also decreased tremor amplitude in an anxiety-provoking situation.

In a 2015 study published in Toxicology in Vitro, scientists investigated the potential neurorestorative effects of CBD and the pathways that mediate it for the treatment of Parkinson’s disease.

They used rat neurons treated with a neurotoxin that is known to induce Parkinson’s disease in vivo and presents with neuroinflammation, excitotoxicity, mitochondrial dysfunction and reduced neurotrophic support. Cell viability, neuritogenesis (the process of forming of new neurites), neural growth factor (NGF) and neuronal protein expression, and the involvement of NGF receptors after CBD exposure were measured.

The data indicated that CBD has neuroprotective effects on neural cells that involves neuritogenesis, NGF receptors as well as an increased expression of axonal and synaptic proteins leading them to conclude that the neuroprotective effects of CBD might be beneficial in Parkinson’s disease.

Anecdotal Evidence – using CBD oil for Parkinson’s

The scientific evidence seems to indicate that CBD has the potential to improve quality of life for patients with Parkinson’s disease in addition to reducing neuroinflammation and oxidative stress as well as induce neurogenesis and neuritogenesis that can potentially slow or even reverse disease progression. Anecdotal evidence also shows that CBD may improve Parkinson’s disease symptoms in some patients but it would seem that many people find a greater relief and reduction in motor symptoms when using cannabis. In fact, according to this study, while only 4.3% of a self-report survey of patients with Parkinson’s disease used cannabis, it ranked among the most effective complimentary and alternative therapies listed.

CBD as a complementary treatment for Parkinson’s

CBD can also play a role as a complementary therapy to help reduce many of the symptoms associated with the pharmaceutical treatments usually prescribed to patients with Parkinson’s disease. CBD can help alleviate gastrointestinal issues like nausea from side effects of levodopa and safinamide. Likewise, CBD has specifically been shown to help improve complex sleep-related behaviors associated with rapid eye movement sleep behavior disorder as well as psychosis in Parkinson’s disease patients.

Bottom Line

The anti-inflammatory, anti-oxidative, neuroprotective and neuroregenaritive effects of CBD can all prove to make it a promising treatment for Parkinson’s disease, for both symptom reduction as well as even potentially slowing down disease progression. In addition, the data shows that CBD is also effective at improving overall quality of life. However, it would seem that high dosages of 300 mg/day produced the best effects, probably due to CBD being a pleiotropic drug that produces different effects through multiple molecular pathways at different dosages. As always, speak to your treating physician before using CBD to monitor dosage, symptom severity, and other clinical parameters. In addition, CBD is contraindicated with use with certain medications, so they can ensure that your CBD treatment is both safe and effective.

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